S-Bis-(PEG4-Boc)

S-Bis-(PEG4-Boc) is a polyethylene glycol (PEG)-based PROTAC linker. S-Bis-(PEG4-Boc) can be used in the synthesis of a series of PROTACs.

* Please be kindly noted that our services and products can only be used for research to organizations or companies and not intended for any clinical or individuals.

Molecular Formula
C₃₀H₅₈O₁₂S
Molecular Weight
642.84

S-Bis-(PEG4-Boc)

    • Specification
      • Storage
        Please store the product under the recommended conditions in the Certificate of Analysis.
        Shipping
        Room temperature in continental US; may vary elsewhere.
        IUPAC Name
        tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethylsulfanyl]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
    • Properties
      • InChI Key
        WIKZQFVHWCXLGX-UHFFFAOYSA-N
        InChI
        InChI=1S/C30H58O12S/c1-29(2,3)41-27(31)7-9-33-11-13-35-15-17-37-19-21-39-23-25-43-26-24-40-22-20-38-18-16-36-14-12-34-10-8-28(32)42-30(4,5)6/h7-26H2,1-6H3
        Canonical SMILES
        CC(C)(C)OC(=O)CCOCCOCCOCCOCCSCCOCCOCCOCCOCCC(=O)OC(C)(C)C
    • Reference Reading
      • 1. Effects of resistance training intensity on muscle quantity/quality in middle-aged and older people: a randomized controlled trial
        Yuta Otsuka, Yosuke Yamada, Akifumi Maeda, Takayuki Izumo, Tomohiro Rogi, Hiroshi Shibata, Masahiro Fukuda, Takuma Arimitsu, Naokazu Miyamoto, Takeshi Hashimoto J Cachexia Sarcopenia Muscle. 2022 Apr;13(2):894-908.doi: 10.1002/jcsm.12941.Epub 2022 Feb 20.
        Background:A sarcopenia diagnosis is confirmed by the presence of low muscle quantity or quality under the 2018 revised definition by the European Working Group on Sarcopenia in Older People 2. Imaging methods [i.e. magnetic resonance imaging (MRI)], dual-energy X-ray absorptiometry (DXA), and bioelectrical impedance analysis are tools to evaluate muscle quantity or quality. The present study aimed to investigate whether and how low-intensity and moderate-intensity resistance training improved both muscle quantity and quality measured by MRI, DXA, and segmental bioelectrical impedance spectroscopy (S-BIS) in middle-aged and older people.
        2. Dicarbonyl-chlorido(phen-oxy-thio-carbonyl-κC,S)bis-(triphenyl-phosphane-κP)molybdenum(II)
        Gene-Hsiang Lee, Hsiao-Fen Wang, Kuang-Hway Yih, Shou-Ling Huang Acta Crystallogr Sect E Struct Rep Online. 2010 Dec 24;67(Pt 1):m117-8.doi: 10.1107/S1600536810052530.
        In the title complex, [Mo(C(7)H(5)OS)Cl(C(18)H(15)P)(2)(CO)(2)], the geometry around the metal atom is a capped octa-hedron. The phen-oxy-thio-carbonyl ligand coordinates the Mo(II) atom through the C and S atoms. A one-dimensional structure is formed by π-π inter-molecular inter-actions and a supra-molecular aggregation is determined by inter-molecular C-H⋯O, C-H⋯Cl, C-H⋯π(arene) hydrogen bonds and CO⋯π(arene) inter-actions [O⋯centroid distances = 3.485 (4) and 3.722 (3) Å].
        3. trans-Bis(μ-2-hydroxy-ethanethiol-ato-κS:S)bis-[dinitro-syliron(II)](Fe-Fe)
        Hon Man Lee, Show-Jen Chiou Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 18;65(Pt 12):m1600.doi: 10.1107/S1600536809048065.
        The title complex, [Fe(2)(C(2)H(5)OS)(2)(NO)(4)], lies on a crystallographic inversion center. The Fe-Fe distance is characteristic of a metal-metal bond. In the crystal structure, inter-molecular O-H⋯O hydrogen bonds link complex mol-ecules into a two-dimensional network.
Bio Calculators
Stock concentration: *
Desired final volume: *
Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
g
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