DSPE-PEG47-acid
Cat No.: BP-501944
4.5 
DSPE-PEG47-acid is an amphiphilic, carboxyl-terminated polyethylene glycol (PEG) linker built on a phospholipid anchor (DSPE), providing a long, flexible hydrophilic spacer between a lipid-like moiety and a reactive terminal carboxylic acid. In PROTAC and targeted degradation workflows, such PEG linkers are commonly used to tune solubility, reduce nonspecific hydrophobic interactions, and spatially separate binding and effector domains so that productive ternary complex formation can occur more efficiently. The terminal acid enables straightforward conjugation strategies (for example, amide coupling or activation-based linkage) to attach the PEG spacer to ligands, handles, or delivery-compatible components while maintaining a defined, hydrated environment around the conjugate. This product is valuable for researchers engineering degraders that require improved aqueous handling, minimized aggregation, and controlled linker length to optimize degradation potency and experimental reproducibility.
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* For research and manufacturing use only. Not for human or clinical use.
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Popular Publications Citing BOC Sciences Products
DSPE-PEG47-acid is a PEG-based lipid linker designed to support PROTAC assembly by providing a flexible, hydrophilic spacer that can improve effective reach and conformational freedom between the targeting ligand and the E3 ligase-binding moiety. Its amphiphilic character and terminal carboxylic acid facilitate robust conjugation strategies commonly used in targeted protein degradation research. The detailed structural and reactivity considerations are provided below to guide experimental design and synthesis planning.
Structure: The linker combines a phospholipid (DSPE) hydrophobic anchor with a poly(ethylene glycol) chain that confers water compatibility and chain flexibility. A terminal carboxylic acid provides a reactive functional group for amide or ester bond formation. Ether linkages within PEG and polar headgroup interactions support stable conjugate behavior in aqueous media.
Reactivity: The carboxylic acid terminus is suitable for coupling reactions to amine-bearing PROTAC components via standard carbodiimide-mediated amide formation or activated-acid strategies. Typical conditions use carbodiimides with an auxiliary base in compatible solvents such as DMF or DMSO, with temperature and pH adjusted to minimize side reactions. The mechanism proceeds through formation of an activated ester/intermediate followed by nucleophilic acyl substitution by the amine.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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