(S,R,S)-AHPC-PEG2-NH2 dihydrochloride - CAS 2341796-76-5

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride dihydrochloride is a synthetic E3 ligand-linker conjugate containing a von-Hippel-Lindau (VHL) ligand based on VH032 and a PEG linker of 2 O(CH2)2 units with terminal amine, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand.

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Molecular Formula
C₂₈H₄₃Cl₂N₅O₆S
Molecular Weight
648.64

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride

    • Specification
      • Purity
        ≥95% by HPLC
        Storage
        Store at -20°C
        Shipping
        Room temperature in continental US; may vary elsewhere.
        IUPAC Name
        (2S,4R)-1-[(2S)-2-[[2-[2-(2-aminoethoxy)ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;dihydrochloride
        Synonyms
        VH032-PEG2-NH2 dihydrochloride
    • Properties
      • InChI
        1S/C28H41N5O6S.2ClH/c1-18-24(40-17-31-18)20-7-5-19(6-8-20)14-30-26(36)22-13-21(34)15-33(22)27(37)25(28(2,3)4)32-23(35)16-39-12-11-38-10-9-29;;/h5-8,17,21-22,25,34H,9-16,29H2,1-4H3,(H,30,36)(H,32,35);2*1H/t21-,22+,25-;;/m1../s1
        Canonical SMILES
        CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCN)=O)=O)O)=O)SC=N1.Cl.Cl
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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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