HO-PEG15-OH
CAS No.: 28821-35-4
Cat No.: BP-501530
Purity: 98%
4.5 
HO-PEG15-OH is a linear, hydroxyl-terminated polyethylene glycol linker featuring a PEG chain long enough to provide a flexible, hydrophilic spacer between PROTAC-relevant functional groups. Its terminal alcohols enable straightforward conjugation chemistry, allowing attachment to warhead or ligand scaffolds through common coupling strategies (e.g., ester or ether formation after activation of the termini), while the PEG backbone maintains solubility and reduces nonspecific hydrophobic interactions. In PROTAC design, such PEG spacers can modulate the effective distance and relative orientation between the target-binding moiety and the E3-recruiting ligand, thereby influencing ternary complex formation and degradation potency. The product is valuable for researchers seeking to tune linker length and physicochemical properties to improve experimental tractability, minimize aggregation, and systematically optimize targeted protein degradation constructs.
Structure of 28821-35-4
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* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| 1 g | $399 | In stock |
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HO-PEG15-OH is a polyethylene glycol-based bifunctional linker designed to support PROTAC assembly by providing flexible spacing between a target-binding ligand and an E3 ligase recruiter. Its ether-rich backbone promotes conformational mobility and can improve effective reach and productive ternary complex formation. The subsequent points describe its structural attributes and practical considerations for linker incorporation into PROTAC constructs.
Structure: HO-PEG15-OH is a PEG chain terminated with hydroxyl groups, featuring repeating ether linkages that confer hydrophilicity and chain flexibility. The molecule is dominated by C–O and C–C connectivity along the polymer backbone, with terminal O–H functionalities enabling derivatization. Its ether-rich architecture supports aqueous compatibility.
Reactivity: For PROTAC construction, terminal hydroxyl groups are typically converted to activated intermediates (for example, via esterification or carbonate/mesylate formation) to enable subsequent coupling to ligand functional handles such as carboxylic acids, amines, or hydrazides. Common approaches use mild base and coupling reagents under anhydrous conditions, followed by nucleophilic substitution or acylation to form stable linkages. Selection of solvent and temperature is guided by the stability of both ligands and the PEG chain.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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