(S,R,S)-AHPC-PEG5-Alkyne

Cat No.: BP-100050 4.5

(S,R,S)-AHPC-PEG5-Alkyne is a crosslinker−E3 ligase ligand conjugate consisting of a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with terminal alkyne for click chemistry with an azide on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.

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Category

E3 Ligase Ligand-Linker Conjugate

Molecular Formula

C36H52N4O9S

Molecular Weight

716.88

* For research and manufacturing use only. Not for human or clinical use.

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Specification
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ShelfLife

2 years

Storage

-20°C

Synonyms

(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13,16,19-pentaoxa-3-azadocos-21-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂