1-Acetyloxy-2,5-dioxopyrrolidine-3-sulfonic acid - CAS 152305-87-8

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Sulfo-NHS-Acetate is a PROTAC linker, which is composed of alkyl chains. Sulfo-NHS-Acetate can be used to synthesize a range of PROTACs.

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Molecular Formula

C6H7NO7S

Molecular Weight

237.19

1-Acetyloxy-2,5-dioxopyrrolidine-3-sulfonic acid

- Specification
  - Purity
    
    95%
    
    Storage
    
    Please store the product under the recommended conditions in the Certificate of Analysis.
    
    Shipping
    
    Room temperature in continental US; may vary elsewhere.
    
    IUPAC Name
    
    1-acetyloxy-2,5-dioxopyrrolidine-3-sulfonic acid
    
    Synonyms
    
    152305-87-8; 1-Acetoxy-2,5-dioxopyrrolidine-3-sulfonicacid; 1-acetyloxy-2,5-dioxopyrrolidine-3-sulfonicacid; 3-Pyrrolidinesulfonicacid,1-(acetyloxy)-2,5-dioxo-; Sulfosuccinimidylacetate; 1-(acetyloxy)-2,5-dioxopyrrolidine-3-sulfonicacid
- Properties
  - Density
    
    1.8g/cm3
    
    InChI Key
    
    MDUQWFYJHRLNRN-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C6H7NO7S/c1-3(8)14-7-5(9)2-4(6(7)10)15(11,12)13/h4H,2H2,1H3,(H,11,12,13)
    
    Canonical SMILES
    
    CC(=O)ON1C(=O)CC(C1=O)S(=O)(=O)O
- Reference Reading
  - 1.Formation of a cross-linking complex of dinitrogenase reductase-activating glycohydrolase (DRAG) with membrane proteins from Rhodospirillum rubrum chromatophores.
    
    Akentieva N1. Biochemistry (Mosc). 2008 Feb;73(2):171-7.
    
    Association of dinitrogenase reductase-activating glycohydrolase (DRAG) with membrane proteins of chromatophores has been investigated. The formation of a multicomponent complex between DRAG and membrane proteins was demonstrated in the presence of glutaraldehyde and EDC/NHS (N-(3-dimethylaminopropyl)-N -ethylcarbodiimide hydrochloride/hydroxy-2,5-dioxopyrrolidine-3-sulfonic acid sodium salt). Complex formation was observed both in native chromatophore membrane and in chromatophores treated with 0.5 M NaCl in the presence of homogeneous DRAG and glutaraldehyde in cross-reaction. The molecular weight of the complex was around 200 kD, which is consistent with the association of DRAG with three or more chromatophore membrane proteins. A specific complex with molecular weight of about 75 kD was formed only in the presence of EDC/NHS in the cross-linking reaction. It was demonstrated that ammonium transport protein and P11 protein are possible candidates for association with DRAG in chromatophore membranes.

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