1-Acetyloxy-2,5-dioxopyrrolidine-3-sulfonic acid

 CAS No.: 152305-87-8  Cat No.: BP-500506  Purity: 95% 4.5  

Sulfo-NHS-Acetate is a PROTAC linker, which is composed of alkyl chains. Sulfo-NHS-Acetate can be used to synthesize a range of PROTACs.

1-Acetyloxy-2,5-dioxopyrrolidine-3-sulfonic acid

Structure of 152305-87-8

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PROTAC Linker
Molecular Formula
C6H7NO7S
Molecular Weight
237.19

* For research and manufacturing use only. Not for human or clinical use.

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Purity
95%
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
1-acetyloxy-2,5-dioxopyrrolidine-3-sulfonic acid
Synonyms
152305-87-8; 1-Acetoxy-2,5-dioxopyrrolidine-3-sulfonicacid; 1-acetyloxy-2,5-dioxopyrrolidine-3-sulfonicacid; 3-Pyrrolidinesulfonicacid,1-(acetyloxy)-2,5-dioxo-; Sulfosuccinimidylacetate; 1-(acetyloxy)-2,5-dioxopyrrolidine-3-sulfonicacid
Density
1.8g/cm3
InChI Key
MDUQWFYJHRLNRN-UHFFFAOYSA-N
InChI
InChI=1S/C6H7NO7S/c1-3(8)14-7-5(9)2-4(6(7)10)15(11,12)13/h4H,2H2,1H3,(H,11,12,13)
Canonical SMILES
CC(=O)ON1C(=O)CC(C1=O)S(=O)(=O)O
1.Formation of a cross-linking complex of dinitrogenase reductase-activating glycohydrolase (DRAG) with membrane proteins from Rhodospirillum rubrum chromatophores.
Akentieva N1. Biochemistry (Mosc). 2008 Feb;73(2):171-7.
Association of dinitrogenase reductase-activating glycohydrolase (DRAG) with membrane proteins of chromatophores has been investigated. The formation of a multicomponent complex between DRAG and membrane proteins was demonstrated in the presence of glutaraldehyde and EDC/NHS (N-(3-dimethylaminopropyl)-N -ethylcarbodiimide hydrochloride/hydroxy-2,5-dioxopyrrolidine-3-sulfonic acid sodium salt). Complex formation was observed both in native chromatophore membrane and in chromatophores treated with 0.5 M NaCl in the presence of homogeneous DRAG and glutaraldehyde in cross-reaction. The molecular weight of the complex was around 200 kD, which is consistent with the association of DRAG with three or more chromatophore membrane proteins. A specific complex with molecular weight of about 75 kD was formed only in the presence of EDC/NHS in the cross-linking reaction. It was demonstrated that ammonium transport protein and P11 protein are possible candidates for association with DRAG in chromatophore membranes.

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