Name: t-Boc-N-amido-PEG7-alcohol
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DCM, DMF, DMSO, Water

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C

Shipping

-20°C (International: -20°C)

IUPACName

tert-butyl N-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate

Synonyms

NHBoc-PEG7-OH; BocNH-PEG7-OH; tert-butyl (20-hydroxy-3,6,9,12,15,18-hexaoxaicosyl)carbamate; N-Boc-PEG7-alcohol; 20-(Boc-amino)-3,6,9,12,15,18-hexaoxa-1-icosanol; 2-[2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylcarbamic acid tert-butyl ester; 5,8,11,14,17,20-Hexaoxa-2-azadocosanoic acid, 22-hydroxy-, 1,1-dimethylethyl ester; 2-Methyl-2-propanyl (20-hydroxy-3,6,9,12,15,18-hexaoxaicos-1-yl)carbamate; Carbamic acid, N-(20-hydroxy-3,6,9,12,15,18-hexaoxaeicos-1-yl)-, 1,1-dimethylethyl ester

Boiling Point

521.1±50.0 °C at 760 mmHg

Density

1.090±0.06 g/cm3 (Predicted)

InChI Key

FOYKHCLPZWXBOB-UHFFFAOYSA-N

InChI

InChI=1S/C19H39NO9/c1-19(2,3)29-18(22)20-4-6-23-8-10-25-12-14-27-16-17-28-15-13-26-11-9-24-7-5-21/h21H,4-17H2,1-3H3,(H,20,22)

SMILES

CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCO

t-Boc-N-amido-PEG7-alcohol is a protected amine PEG alcohol linker for staged PROTAC synthesis. The PEG segment supports hydrophilicity and flexibility, while the terminal alcohol and Boc-protected amine enable orthogonal derivatization. The structure and practical reactivity are described below.

Structure: The linker contains an oligoethylene glycol chain, a terminal alcohol, an amide-containing connection, and a Boc-protected amine motif. These features provide polarity, hydrogen-bonding capacity, and controlled synthetic accessibility.

Reactivity: The alcohol can be converted into activated carbonates, esters, sulfonates, or other leaving-group derivatives for attachment to ligand fragments. Acid-mediated Boc removal reveals an aliphatic amine for amide, urea, carbamate, or sulfonamide formation. Mild, orthogonal conditions help preserve PEG and amide integrity.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂