m-PEG8-COOH

Name: m-PEG8-COOH
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 1093647-41-6

Cat No.: BP-500345

Purity: ≥95% 4.5

m-PEG8-COOH is a methoxy-terminated PEG carboxylic acid linker component with an extended ether-rich hydrophilic chain and a terminal acid handle. The PEG segment can contribute flexibility, polarity, and improved aqueous compatibility, while the carboxylic acid can be activated for amide coupling with amine-bearing ligands, recruiters, or linker intermediates. In PROTAC design, this product is suitable for introducing a polar PEG spacer or terminal solubilizing segment into degrader analogues. It is valuable for studying how PEG-based linker hydrophilicity, spacing, and conformational freedom influence ternary complex formation, ubiquitination-related readouts, and targeted protein degradation assay performance.

Structure of 1093647-41-6

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Category

PROTAC Linker

Molecular Formula

C18H36O10

Molecular Weight

412.47

Appearance

Pale Yellow Oily Liquid

* For research and manufacturing use only. Not for human or clinical use.

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Comprehensive PROTAC Platform
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Purity

≥95%

Solubility

Soluble in DCM, DMF, DMSO, Water

Appearance

Pale Yellow Oily Liquid

Storage

Store at 2-8°C

Shipping

Room temperature

IUPACName

3-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

mPEG7-propionic acid; m-PEG8-acid; 4,7,10,13,16,19,22,25-Octaoxahexacosanoic acid; mPEG7-CH2CH2COOH; 2,5,8,11,14,17,20,23-Octaoxahexacosan-26-oic acid; MPEG7-OCH2CH2COOH

Boiling Point

503.0±50.0 °C at 760 mmHg

Density

1.111±0.06 g/cm3 (Predicted)

InChI Key

JHUSQXBQANBSDC-UHFFFAOYSA-N

InChI

InChI=1S/C18H36O10/c1-21-4-5-23-8-9-25-12-13-27-16-17-28-15-14-26-11-10-24-7-6-22-3-2-18(19)20/h2-17H2,1H3,(H,19,20)

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

m-PEG8-COOH is a methoxy-capped PEG acid linker that provides a hydrophilic and flexible spacer for PROTAC construction. Its terminal carboxylic acid enables reliable coupling to amine-bearing ligand fragments, while the capped PEG end limits competing functionalization. Detailed features are provided below.

Structure: The molecule contains a methoxy-terminated oligoethylene glycol chain and a terminal carboxylic acid. Ether linkages provide polarity and flexibility, while the acid group serves as a defined conjugation handle.

Reactivity: The carboxylic acid can be activated with carbodiimide, uronium, or phosphonium coupling systems and reacted with amine-containing PROTAC fragments to form amide bonds. Reactions are typically performed in dry polar organic solvents with organic base. The methoxy terminus remains largely inert during coupling.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂