Name: m-PEG3-COOH
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DCM, DMF, DMSO, Water

Appearance

Pale Yellow or Colorless Oily Liquid

Storage

Store at 2-8°C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[2-(2-methoxyethoxy)ethoxy]propanoic acid

Synonyms

m-PEG2-CH2CH2COOH; m-PEG3-acid; Propanoic acid, 3-[2-(2-methoxyethoxy)ethoxy]-; COOHCH2CH2-PEG2-OME

Boiling Point

301.7±27.0 °C at 760 mmHg

Density

1.102±0.06 g/cm3 (Predicted)

InChI Key

HFCYTEWOPOCEBG-UHFFFAOYSA-N

InChI

InChI=1S/C8H16O5/c1-11-4-5-13-7-6-12-3-2-8(9)10/h2-7H2,1H3,(H,9,10)

SMILES

COCCOCCOCCC(=O)O

m-PEG3-COOH is a methoxy-capped PEG carboxylic acid linker used to introduce a short hydrophilic spacer into PROTAC constructs. It combines PEG-derived flexibility with a single acid coupling handle, making it useful for directional linker attachment. Detailed features are provided below.

Structure: The structure consists of a methoxy-terminated oligoethylene glycol chain ending in a carboxylic acid. Ether bonds provide conformational freedom and polarity, while the terminal acid enables covalent conjugation.

Reactivity: The carboxylic acid can be activated for amide-bond formation with amine-containing target or E3-ligand fragments. Carbodiimide, uronium, or phosphonium coupling conditions are commonly suitable. Reactions should use compatible base and polar organic solvents, with minimized water exposure to reduce activated-acid hydrolysis.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂