Name: Hydroxy-PEG2-t-butyl acetate
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>95%

Appearance

Transparent Liquid

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl 2-[2-(2-hydroxyethoxy)ethoxy]acetate

Synonyms

2-[2-(2-hydroxyethoxy)ethoxy]acetic acid tert-butyl ester; tert-butyl 2-[2-(2-hydroxyethoxy)ethoxy]acetate

Boiling Point

306.1±22.0 °C at 760 mmHg

Density

1.1±0.1 g/cm3

InChI Key

LMDJRQVQNFNFAK-UHFFFAOYSA-N

InChI

InChI=1S/C10H20O5/c1-10(2,3)15-9(12)8-14-7-6-13-5-4-11/h11H,4-8H2,1-3H3

SMILES

CC(C)(C)OC(=O)COCCOCCO

Hydroxy-PEG2-t-butyl acetate is a compact PEG linker intermediate bearing a free hydroxyl group and a tert-butyl ester-protected acid equivalent. This design enables alcohol-based functionalization followed by carboxyl unveiling for PROTAC linker elaboration. The structure and reactivity are described below.

Structure: The molecule contains a short oligoethylene glycol segment, a terminal hydroxyl group, and a tert-butyl ester-protected acetate moiety. Ether bonds provide flexibility, while the ester masks a carboxylic acid.

Reactivity: The hydroxyl group can be converted into activated carbonates, esters, or sulfonate leaving groups for coupling to PROTAC fragments. Acidic cleavage of the tert-butyl ester releases a carboxylic acid suitable for amide formation with amine-bearing ligands. Reaction order should preserve orthogonality between alcohol activation and ester deprotection.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂