Name: 6-Aminooxyhexanoic acid hydrobromide
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Price

Stock

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$--

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Purity

95%

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Room temperature in continental US; may vary elsewhere.

IUPACName

6-aminooxyhexanoic acid;hydrobromide

Synonyms

6-aminooxyhexanoicacid; hydrobromide; 6-AMINOOXYHEXANOICACIDHYDROBROMIDE; 448954-98-1; 6-Aminooxy-hexanoicacidhydrobromide; CTK1D4895

Boiling Point

349.5°C at 760 mmHg

InChI Key

BGUDSFOAMPGEOX-UHFFFAOYSA-N

InChI

InChI=1S/C6H13NO3.BrH/c7-10-5-3-1-2-4-6(8)9;/h1-5,7H2,(H,8,9);1H

SMILES

C(CCC(=O)O)CCON.Br

1.[HPLC Fingerprint of Anisodus tanguticus Root].

Jiang YB, Gou Y, Yuan MH, Ma YY, Zhou J, Wu PE. Zhong Yao Cai. 2015 May;38(5):957-61.

OBJECTIVE: To establish an HPLC fingerprint of Anisodus tanguticus root for its quality control.

2.Salt forms of the pharmaceutical amide dihydrocarbamazepine.

Buist AR1, Kennedy AR1. Acta Crystallogr C Struct Chem. 2016 Feb 1;72(Pt 2):155-60. doi: 10.1107/S2053229616001133. Epub 2016 Jan 27.

Carbamazepine (CBZ) is well known as a model active pharmaceutical ingredient used in the study of polymorphism and the generation and comparison of cocrystal forms. The pharmaceutical amide dihydrocarbamazepine (DCBZ) is a less well known material and is largely of interest here as a structural congener of CBZ. Reaction of DCBZ with strong acids results in protonation of the amide functionality at the O atom and gives the salt forms dihydrocarbamazepine hydrochloride {systematic name: [(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)(hydroxy)methylidene]azanium chloride, C15H15N2O(+)·Cl(-)}, dihydrocarbamazepine hydrochloride monohydrate {systematic name: [(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)(hydroxy)methylidene]azanium chloride monohydrate, C15H15N2O(+)·Cl(-)·H2O} and dihydrocarbamazepine hydrobromide monohydrate {systematic name: [(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)(hydroxy)methylidene]azanium bromide monohydrate, C15H15N2O(+)·Br(-)·H2O}.

3.A fluorescence assay for measuring acetylcholinesterase activity in rat blood and a human neuroblastoma cell line (SH-SY5Y).

Santillo MF1, Liu Y2. J Pharmacol Toxicol Methods. 2015 Nov-Dec;76:15-22. doi: 10.1016/j.vascn.2015.07.002. Epub 2015 Jul 9.

Acetylcholinesterase (AChE) is an enzyme responsible for metabolism of the neurotransmitter acetylcholine, and inhibition of AChE can have therapeutic applications (e.g., drugs for Alzheimer's disease) or neurotoxic consequences (e.g., pesticides). A common absorbance-based AChE activity assay that uses 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB) can have limited sensitivity and be prone to interference. Therefore, an alternative assay was developed, in which AChE activity was determined by measuring fluorescence of resorufin produced from coupled enzyme reactions involving acetylcholine and Amplex Red (10-acetyl-3,7-dihydroxyphenoxazine). The Amplex Red assay was used for two separate applications. First, AChE activity was measured in rat whole blood, which is a biomarker for exposure to AChE inhibitor pesticides. Activity was quantified from a 10(5)-fold dilution of whole blood, and there was a linear correlation between Amplex Red and DTNB assays.

4.Polythiophene derivative on quartz resonators for miRNA capture and assay.

Palaniappan A1, Cheema JA, Rajwar D, Ammanath G, Xiaohu L, Seng Koon L, Yi W, Yildiz UH, Liedberg B. Analyst. 2015 Dec 7;140(23):7912-7. doi: 10.1039/c5an01663k. Epub 2015 Oct 19.

A novel approach for miRNA assay using a cationic polythiophene derivative, poly[3-(3'-N,N,N-triethylamino-1'-propyloxy)-4-methyl-2,5-thiophene hydrobromide] (PT), immobilized on a quartz resonator is proposed. The cationic PT enables capturing of all RNA sequences in the sample matrix via electrostatic interactions, resulting in the formation of PT-RNA duplex structures on quartz resonators. Biotinylated peptide nucleic acid (b-PNA) sequences are subsequently utilized for the RNA assay, upon monitoring the PT-RNA-b-PNA triplex formation. Signal amplification is achieved by anchoring avidin coated nanoparticles to b-PNA in order to yield responses at clinically relevant concentration regimes. Unlike conventional nucleic acid assay methodologies that usually quantify a specific sequence of RNA, the proposed approach enables the assay of any RNA sequence in the sample matrix upon hybridization with a PNA sequence complementary to the RNA of interest.

6-Aminooxyhexanoic acid hydrobromide, provides a chemically versatile aminooxy-functional handle for constructing degraders through oxime-based conjugation strategies. Its bifunctional design supports robust coupling to aldehyde-bearing or carbonyl-containing ligands, enabling controlled formation of stable linkages that are commonly used to connect targeting and recruiting modules. The subsequent points describe the structural features and practical reactivity considerations for PROTAC assembly in detail below.

Structure: The linker contains an aminooxy group and a carboxylic acid chain, present as a hydrobromide salt that improves handling and aqueous compatibility. It features an aliphatic carbon chain with an aminooxy functionality capable of forming oxime linkages, alongside ionic interactions from the hydrobromide counterion.

Reactivity: Aminooxy linkers typically react with aldehydes or other carbonyl equivalents under mildly acidic conditions to form oxime or related oxime-derived linkages, often proceeding via condensation followed by stabilization of the C=N bond. For PROTAC assembly, aldehyde-functional ligands are commonly used; solvents such as aqueous buffers with suitable co-solvents can support solubility, while acid catalysts or dehydrating/condensation-promoting conditions may be employed to drive the coupling efficiently.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂