Amino-PEG10-t-butyl ester
CAS No.: 1818294-42-6
Cat No.: BP-501090
Purity: >97%
4.5 
Amino-PEG10-t-butyl ester is a bifunctional polyethylene glycol (PEG) linker featuring a terminal primary amine and a protected carboxyl group masked as a tert-butyl ester. Structurally, it provides a flexible, hydrophilic chain of approximately ten ethylene glycol units that can project reactive groups away from bulky ligands, improving effective conjugation geometry and reducing steric interference. In PROTAC and targeted protein degradation workflows, the amine handle enables coupling to electrophilic warheads or E3-ligase–binding moieties through amide-forming or other standard bioconjugation chemistries, while the tert-butyl ester can be used as a protected carboxyl equivalent for subsequent activation/deprotection steps to generate an acid for controlled linkage formation. This linker value lies in its ability to tune linker length and polarity, often enhancing soluble behavior and supporting efficient formation of heterobifunctional degraders for systematic structure–activity studies.
Structure of 1818294-42-6
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This Amino-PEG10-t-butyl ester linker is designed to serve as a versatile polyethylene glycol (PEG)-based spacer bearing an amino functionality and a protected carboxyl group. Its hydrophilic PEG character supports solubility and favorable linker flexibility in targeted protein degradation constructs, while the t-butyl ester enables controlled downstream conjugation. The molecule is well suited for assembling PROTACs where modular attachment of ligands and controlled handling of functional groups are required; detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a PEG oligomer segment connected to an amino group and a carboxyl function masked as a t-butyl ester. It contains ether linkages along the PEG chain, an amine for coupling, and an ester carbonyl that is stable under mild conditions yet removable under acidic cleavage.
Reactivity: For PROTAC assembly, the amino group can be used for amide or urea bond formation via standard coupling chemistries, typically employing activated carboxylic acid derivatives. The t-butyl ester can be deprotected under acidic conditions to reveal a carboxylic acid for subsequent conjugation. Common approaches use peptide-coupling reagents and compatible solvents such as polar aprotic media, with reaction monitoring to ensure selective deprotection and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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