Bromo-PEG2-alcohol
CAS No.: 57641-66-4
Cat No.: BP-501640
Purity: ≥95%
4.5 
Bromo-PEG2-alcohol is a short, bromo-functionalized polyethylene glycol linker bearing a terminal alcohol, providing a flexible, hydrophilic spacer with a reactive bromide handle for subsequent conjugation chemistry. Structurally, it contains an ether-linked PEG chain of two ethylene glycol units, terminated by an alcohol group that can be used for further derivatization (e.g., esterification, ether formation, or attachment to other PROTAC fragments), while the bromine enables coupling through nucleophilic substitution or related alkylation strategies. In PROTAC design, such PEG linkers are commonly employed to tune the spatial separation and conformational freedom between a targeting ligand and an E3 ligase-binding moiety, helping to promote productive ternary complex formation and improving solubility and handling of the final conjugate. This linker is therefore valuable for constructing modular targeted degradation probes, allowing researchers to systematically vary attachment points and linker geometry while maintaining aqueous compatibility for in vitro assays.
Structure of 57641-66-4
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Bromo-PEG2-alcohol is a PEG-based bifunctional linker designed for modular synthesis of PROTACs, enabling efficient conjugation between a ligand warhead and an E3 ligase-binding moiety. Its ether-rich polyethylene glycol segment provides conformational flexibility and improved solubility, while the terminal bromo group serves as a versatile electrophile for downstream coupling. The following sections describe the linker’s structural features and practical reactivity considerations for constructing targeted protein degraders.
Structure: The linker contains a short polyethylene glycol chain featuring ether linkages that impart flexibility and hydrophilicity. A terminal primary alcohol provides a hydrogen-bonding handle, while the bromo substituent offers an alkyl-halide electrophilic site. The overall structure is consistent with a PEG alcohol bearing a reactive bromomethyl functionality.
Reactivity: The bromo group can participate in nucleophilic substitution reactions with appropriately prepared nucleophiles (for example, amines or oxygen-centered nucleophiles) under standard organic synthesis conditions. Coupling is typically performed in polar aprotic or mixed solvent systems to promote SN2-type displacement, with base and temperature selected to balance reactivity and minimize side reactions. The alcohol functionality can be retained or converted (for example, via activation strategies) depending on the intended PROTAC architecture.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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