m-PEG3-Sulfone-PEG4-propargyl
CAS No.: 2055041-02-4
Cat No.: BP-500696
Purity: 98%
4.5 
m-PEG3-Sulfone-PEG4-propargyl is a heterobifunctional PEG-based PROTAC linker featuring a sulfone-containing junction that connects a short PEG3 segment to a longer PEG4 segment, terminating in a propargyl group for bioorthogonal conjugation. The PEG chains provide hydrophilicity and conformational flexibility, helping to reduce nonspecific interactions and to spatially present the reactive handle for efficient attachment to targeting ligands or E3-recruiting moieties. The sulfone linkage offers a defined, relatively rigid connection point that can improve reproducibility of linker geometry compared with purely flexible ether-only linkers, which is important for maintaining productive ternary complex formation in targeted protein degradation. In PROTAC workflows, this linker supports modular synthesis via propargyl-mediated coupling (e.g., click-type strategies) while the PEG framework can tune solubility and cell compatibility. It is therefore valuable for researchers optimizing linker length, flexibility, and conjugation efficiency in targeted degradation studies.
Structure of 2055041-02-4
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This m-PEG3-Sulfone-PEG4-propargyl linker is designed for modular PROTAC assembly, combining a flexible polyethylene glycol scaffold with a sulfone-containing segment and a terminal propargyl handle for orthogonal conjugation. Its ether-rich backbone supports solubility and conformational adaptability, while the sulfone motif can enhance chemical robustness during linker manipulation. The propargyl functionality enables reliable attachment to targeting ligands or warheads, facilitating systematic optimization of linker length, geometry, and degradation performance.
Structure: The linker comprises a sulfone-linked PEG framework with multiple ether linkages that confer high polarity and conformational flexibility. A terminal propargyl group provides an alkynyl functional handle suitable for click-type coupling. Overall, it contains stable C–O and S–O bonded motifs and a carbon–carbon triple bond at the reactive terminus.
Reactivity: The propargyl group is suitable for copper-catalyzed azide–alkyne cycloaddition with azide-bearing partners under standard click conditions, enabling efficient formation of a stable triazole linkage. Typical workflows use inert atmospheres when required, polar aprotic solvents to maintain solubility, and copper catalysts with appropriate ligands to control reaction rate and minimize side reactions. The sulfone/PEG segments are generally compatible with common coupling and purification steps used in PROTAC synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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