VH032-OH

 CAS No.: 2244684-42-0  Cat No.: BP-200033 4.5  

VH032-OH is a functionalized von-Hippel-Lindau (VHL) ligand containing an E3 ligase ligand with terminal hydroxyl, which can combine with linker for conjugation a target protein ligand to form PROTAC molecule.

VH032-OH

Structure of 2244684-42-0

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Ligand for E3 Ligase
Molecular Formula
C₂₄H₃₂N₄O₅S
Molecular Weight
488.60

* For research and manufacturing use only. Not for human or clinical use.

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Solubility
In DMSO: 100 mg/mL (204.67 mM; Need ultrasonic)
Storage
-20°C, stored under nitrogen; In solvent, -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
(2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[2-hydroxy-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
InChI Key
CUHVZPHLQIBKHX-LVCYWYKZSA-N
InChI
1S/C24H32N4O5S/c1-13-20(34-12-26-13)15-6-7-16(19(31)8-15)10-25-22(32)18-9-17(30)11-28(18)23(33)21(24(3,4)5)27-14(2)29/h6-8,12,17-18,21,30-31H,9-11H2,1-5H3,(H,25,32)(H,27,29)/t17-,18+,21-/m1/s1
Canonical SMILES
CC1=C(C2=CC=C(C(O)=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(C)=O)=O)O)=O)SC=N1
Pub Chem ID
142452655
ConcentrationVolumeMass1 mg5 mg10 mg
1 mM2.05 mL10.23 mL20.47 mL
5 mM0.41 mL2.05 mL4.09 mL
10 mM0.2 mL1.02 mL2.05 mL
50 mM0.04 mL0.2 mL0.41 mL

Stock concentration: *
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Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
g

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