VH032-OH

Background Introduction

VH032-OH is a crucial derivative of VH032, a well-characterized ligand that specifically binds the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex. As an essential building block in the design and synthesis of PROTACs (Proteolysis Targeting Chimeras), VH032-OH features a hydroxyl functional group, allowing facile conjugation to various linkers and target ligands. This structure supports the creation of highly effective heterobifunctional molecules aimed at precision protein degradation.

Mechanism

VH032-OH operates by binding directly to the VHL E3 ligase component, thus facilitating the recruitment of VHL to the PROTAC molecule. When linked to a ligand targeting a protein of interest, VH032-OH enables the formation of a ternary complex that brings the target protein into proximity with the VHL E3 ligase. This interaction drives the ubiquitination and subsequent proteasomal degradation of the target protein, resulting in selective and potent protein knockdown.

Applications

VH032-OH is widely utilized in the design and synthesis of VHL-based PROTACs to achieve targeted and efficient protein degradation. Its reactive hydroxyl moiety is ideal for linker attachment, enabling versatile PROTAC architectures. Key applications include:

• Synthesis of VHL-based PROTAC molecules for drug discovery pipelines
• Target validation and tool compound development in chemical biology
• SAR (structure-activity relationship) studies for optimizing degrader efficacy and selectivity
• Construction of bifunctional molecules for therapeutic and academic research into protein function and pharmacology.

• High-purity compound verified by HPLC, NMR, and LC-MS
• Consistent batch-to-batch reproducibility with complete QC documentation
• Supplied with COA, MSDS, and analytical data for traceability
• Reliable global shipping with stability-guaranteed packaging
• Dedicated technical support and optional custom synthesis service
• Demonstrates strong binding affinity to CRBN, VHL, or other E3 ligases
• Enables stable E3 ligase recruitment for targeted protein degradation
• Highly selective VHL E3 ligase ligand enables targeted protein degradation for advanced PROTAC design.
• Hydroxyl functional group offers versatile conjugation options, enhancing PROTAC synthesis flexibility and efficiency.

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.23 mL	20.47 mL
5 mM	0.41 mL	2.05 mL	4.09 mL
10 mM	0.2 mL	1.02 mL	2.05 mL
50 mM	0.04 mL	0.2 mL	0.41 mL