Name: PROTAC MDM2 Degrader-2
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Solubility

10 mM in DMSO

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Synonyms

PROTAC MDM2 Degrader 2; 2-[4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-2-oxopiperazin-1-yl]-N-[2-[2-[2-[[2-[4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-2-oxopiperazin-1-yl]acetyl]amino]ethoxy]ethoxy]ethyl]acetamide

InChI Key

WZLSSHVSGKCEKQ-AKOOKZATSA-N

InChI

InChI=1S/C70H76Cl4N10O12/c1-43(2)95-57-37-53(91-5)23-25-55(57)67-77-63(45-7-15-49(71)16-8-45)65(47-11-19-51(73)20-12-47)83(67)69(89)81-31-29-79(61(87)41-81)39-59(85)75-27-33-93-35-36-94-34-28-76-60(86)40-80-30-32-82(42-62(80)88)70(90)84-66(48-13-21-52(74)22-14-48)64(46-9-17-50(72)18-10-46)78-68(84)56-26-24-54(92-6)38-58(56)96-44(3)4/h7-26,37-38,43-44,63-66H,27-36,39-42H2,1-6H3,(H,75,85)(H,76,86)/t63-,64-,65+,66+/m1/s1

SMILES

CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCN(C(=O)C3)CC(=O)NCCOCCOCCNC(=O)CN4CCN(CC4=O)C(=O)N5C(C(N=C5C6=C(C=C(C=C6)OC)OC(C)C)C7=CC=C(C=C7)Cl)C8=CC=C(C=C8)Cl)C9=CC=C(C=C9)Cl)C1=CC=C(C=C1)Cl

Mechanism

Target: Targets MDM2 E3 ligase protein for experimental targeted protein degradation studies.

Binding Site: Binds the MDM2 p53-binding cleft and recruited E3 ligase ligand site to support productive ternary complex formation.

Mechanism of Action: PROTAC MDM2 Degrader-2 is designed for use in PROTAC or targeted protein degradation experiments directed toward MDM2 E3 ligase protein. The bifunctional molecule links a target-recognition element to cereblon, promoting proximity between the protein of interest and ubiquitination machinery. Productive ternary-complex formation can drive polyubiquitination and proteasome-dependent target depletion, allowing researchers to compare pharmacological inhibition with protein removal. It is suitable for evaluating degradation potency, kinetics, pathway selectivity, and downstream signaling consequences in engineered or disease-relevant cellular models.

Applications

• PROTAC-Mediated MDM2 Degradation: This product facilitates the targeted degradation of MDM2, a key regulator in the p53 tumor suppressor pathway. By employing a bifunctional molecule, it recruits E3 ligases to ubiquitinate and degrade MDM2, providing a powerful tool for studying MDM2's role in cancer biology and therapeutic resistance mechanisms.

• Targeted Protein Degradation in Oncology: PROTAC MDM2 Degrader-2 allows researchers to explore novel cancer treatment strategies by effectively reducing MDM2 levels. This application aids in elucidating the impact of MDM2 degradation on tumor suppression and offers insights into the development of new therapeutic approaches targeting oncogenic pathways.

• Investigating Protein-Protein Interactions: Utilizing PROTAC technology, this degrader enables the study of protein-protein interactions involving MDM2. By selectively degrading MDM2, researchers can dissect its interaction networks and downstream effects, advancing the understanding of cellular processes and signaling pathways influenced by MDM2.

• Modulating Cellular Pathways: The targeted degradation of MDM2 using this PROTAC compound offers a strategic approach to modulate cellular pathways. Researchers can investigate the consequences of MDM2 depletion on cell cycle regulation, apoptosis, and DNA damage response, providing insights into potential intervention points for therapeutic development.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂