Name: 7-Octynoic Acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Solubility

In DMSO: 150 mg/mL (1070.05 mM; Need ultrasonic)<br/>In H2O: 5 mg/mL (35.67 mM; Need ultrasonic)

Storage

Pure form, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

oct-7-ynoic acid

Synonyms

7-octynoic acid; oct-7-ynoic acid

InChI Key

WJBHDZBQZOMDFF-UHFFFAOYSA-N

InChI

InChI=1S/C8H12O2/c1-2-3-4-5-6-7-8(9)10/h1H,3-7H2,(H,9,10)

SMILES

C#CCCCCCC(=O)O

1. Influence of the terminal group on the thermal decomposition reactions of carboxylic acids on copper: nature of the carbonaceous film

Robert Bavisotto, Resham Rana, Nicholas Hopper, Kaiming Hou, Wilfred T Tysoe Phys Chem Chem Phys. 2021 Aug 28;23(32):17663-17671. doi: 10.1039/d1cp02078a.Epub 2021 Aug 10.

The effect of the terminal groups on the nature of the films formed by the thermal decomposition of carboxylic acids on copper is studied in ultrahigh vacuum using temperature-programmed desorption (TPD), scanning tunneling microscopy (STM) and Auger electron spectroscopy (AES). The influence of the presence of vinyl or alkynyl terminal groups and chain length is studied using heptanoic, octanoic, 6-heptenoic, 7-octenoic, 6-heptynoic and 7-octynoic acids. The carboxylic acids form strongly bound carboxylates following adsorption on copper at room temperature, and thermally decompose between ~500 and 650 K. Previous work has shown that this occurs by the carboxylate plane tilting towards the surface to eliminate carbon dioxide and deposit a hydrocarbon fragment. The fragment can react to evolve hydrogen or form oligomeric species on the surface, where the amount of carbon increases for carboxylic acids that contain terminal functional groups that can anchor to the surface. These results will be used to compare with the carbonaceous films formed by the mechanochemical decomposition of carboxylic acids on copper, which occurs at room temperature. This is expected to lead to less carbon being deposited on the surface than during thermal decomposition.

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	7.1337 mL	35.6684 mL	71.3369 mL
5 mM	1.4267 mL	7.1337 mL	14.2674 mL
10 mM	0.7134 mL	3.5668 mL	7.1337 mL

7-Octynoic Acid, is a fatty-chain alkyne carboxylic acid designed for modular conjugation in PROTAC architectures. Its terminal alkyne functionality enables widely used bioorthogonal and coupling strategies, while the carboxylic acid supports stable amide or ester formation for controlled linker presentation. These features make it a practical building block for assembling targeted protein degraders, with the detailed structural and synthetic considerations provided below.

Structure: 7-Octynoic Acid is a medium-length aliphatic chain bearing a carboxylic acid and an internal alkyne. It contains a terminally reactive carbon–carbon triple bond alongside an acid group, with predominant single-bond connectivity that confers conformational flexibility. The molecule is typically handled as an organic acid with characteristic hydrogen-bonding and polarity.

Reactivity: The carboxylic acid readily participates in standard PROTAC linker coupling via activation to form amides or esters, commonly using carbodiimide-type coupling systems and base in polar aprotic solvents. The alkyne enables click-type conjugations and related alkyne functionalization under conditions compatible with biomolecule conjugates. Mechanistically, coupling proceeds through an activated ester intermediate, while alkyne-based transformations proceed via addition or cycloaddition pathways, often requiring copper catalysts for classic click chemistry.

Stock concentration: *

Desired final volume: *

Desired concentration: *

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂