Pomalidomide-PEG4-CO2H

 CAS No.: 2138440-81-8  Cat No.: BP-100021  Purity: ≥98%  MS  HNMR 4.5  

Pomalidomide-PEG4-CO2H is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal carboxylic acid for reactivity with an amine on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.

Pomalidomide-PEG4-CO2H

Structure of 2138440-81-8

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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C24H31N3O10
Molecular Weight
521.52
Appearance
Yellow Gum

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥98%
Appearance
Yellow Gum
ShelfLife
2 years
Storage
Store at 2-8°C
IUPACName
3-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Synonyms
Thalidomide-NH-PEG4-COOH; Pomalidomide-PEG4-C2-acid; Pomalidomide-PEG4-COOH; Pomalidomide 4'-PEG4-acid; Pomalidomide-PEG4-C2-COOH; 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid; Pomalidomide-PEG4-Acid; 1-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxapentadecan-15-oic acid; 3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Boiling Point
773.6±60.0°C at 760 mmHg
Density
1.4±0.1 g/cm3
InChI Key
CAANPUBZFFRWQP-UHFFFAOYSA-N
InChI
InChI=1S/C24H31N3O10/c28-19-5-4-18(22(31)26-19)27-23(32)16-2-1-3-17(21(16)24(27)33)25-7-9-35-11-13-37-15-14-36-12-10-34-8-6-20(29)30/h1-3,18,25H,4-15H2,(H,29,30)(H,26,28,31)
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCC(=O)O

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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