Name: Pomalidomide-C8-COOH
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Appearance

Yellow Solid

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

IUPACName

9-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]nonanoic acid

Synonyms

Pomalidomide-C8-acid; Pomalidomide-C8-CO2H; Thalidomide-NH-C8-COOH; 9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)nonanoic acid; 9-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}nonanoic acid; Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-; Pomalidomide 4'-alkylC8-acid

Boiling Point

718.9±60.0°C at 760 mmHg

Density

1.4±0.1 g/cm3

InChI Key

OGMJVYCYINHWEJ-UHFFFAOYSA-N

InChI

InChI=1S/C22H27N3O6/c26-17-12-11-16(20(29)24-17)25-21(30)14-8-7-9-15(19(14)22(25)31)23-13-6-4-2-1-3-5-10-18(27)28/h7-9,16,23H,1-6,10-13H2,(H,27,28)(H,24,26,29)

SMILES

C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCCCC(=O)O

The Pomalidomide-C8-COOH E3 Ligase Ligand-Linker Conjugate is a crucial component in the development of PROTACs, facilitating targeted protein degradation by linking an E3 ligase ligand to a target protein ligand. This molecule offers enhanced specificity and efficacy in protein degradation research. The following provides a detailed description of this molecule.

Linker: The linker in this molecule is an 8-carbon aliphatic chain, providing moderate flexibility to accommodate diverse spatial orientations. Its non-cleavable nature ensures the stability of the conjugate, making it suitable for applications requiring sustained interaction between the ligase and the target protein.

Ligand: The ligand is derived from pomalidomide, a thalidomide analog known for its high affinity to the cereblon E3 ligase. Its structural characteristics include a glutarimide ring, which is essential for binding to the E3 ligase, facilitating the recruitment of the ubiquitin-proteasome system.

Reactive Site: The reactive site features a carboxylic acid group, which can couple with amine-containing target protein ligands through amide bond formation. This reaction type is favored for its stability and compatibility with aqueous environments, enabling efficient conjugation under physiological conditions.

Recommended Target Protein Ligand: The recommended warhead for this molecule is an amine-containing moiety, such as those found in lysine residues. This choice offers the advantage of forming stable amide bonds, ensuring robust target engagement. Applications include the development of PROTACs for the selective degradation of proteins implicated in various diseases, enhancing therapeutic research possibilities.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂