Nonoxynol-5

Size	Price	Stock	Quantity
1 g	$1099	In stock

Size

Price

Stock

Quantity

1 g

$1099

In stock

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol

InChI Key

PITRRWWILGYENJ-UHFFFAOYSA-N

InChI

InChI=1S/C25H44O6/c1-2-3-4-5-6-7-8-9-24-10-12-25(13-11-24)31-23-22-30-21-20-29-19-18-28-17-16-27-15-14-26/h10-13,26H,2-9,14-23H2,1H3

Canonical SMILES

CCCCCCCCCC1=CC=C(C=C1)OCCOCCOCCOCCOCCO

1. A modified transmembrane migration method for evaluating the spermicidal potency of some nonoxynol compounds

P B Curtis-Prior, A L Gadd J Pharm Pharmacol . 1988 Mar;40(3):215-6. doi: 10.1111/j.2042-7158.1988.tb05225.x.

The transmembrane migration technique, a simple method in-vitro for quantitatively assessing the effects of a drug on human sperm motility, has been evaluated. The original method has been modified to include a preincubation step, and the incubation time has been reduced to 90 min. In semen samples possessing sperm concentrations of less than 75 x 12(6) spermatozoa mL-1 the volume of the lower reservoir has been reduced to 1 mL. This modified method has been used to compare the spermicidal potency of the widely employed non-ionic surfactant nonoxynol-9, with nonoxynol-5 and nonoxynol-15 (containing, respectively, fewer and more ethylene oxide units per molecule). The rank order of spermicidal potency of the compounds evaluated was nonoxynol-9 = nonoxynol-5 greater than nonoxynol-15.

How does Nonoxynol-5 controlled in a spatiotemporal manner interact with targeted proteins?

Nonoxynol-5 couples the tyrosine phosphorylation sequence of the nerve growth factor receptor tropomyosin receptor kinase A (TrkA) or neuregulin receptor erythrocytic oncogene B3 (ErbB3) to a VHL ligand.

30/4/2020

What are the main processes involved in the formation of the POI-PROTAC-E3 ligase ternary complex by Nonoxynol-5 in cells?

First, E1 activating enzyme activates ubiquitin and transfers it to E2 conjugating enzyme; second, E3 ligase binds POI and E2 conjugating enzyme, allowing ubiquitin to attach to POI; finally, proteasome recognizes and degrades ubiquitin-tagged POI. Once inside the cell, the POI ligand specifically binds to the corresponding POI, while the other ligand binds to the E3 ligase. Thus forming a POI-PROTAC-E3 ligase ternary complex.

23/7/2020

How does Nonoxynol-5 induce intracellular targeted protein degradation?

Nonoxynol-5 works by inducing the proximity between intracellular target proteins and E3 ligase complexes, these heterobifunctional molecules catalyze the formation of ternary complexes leading to target protein ubiquitination and its proteosome-mediated degradation.

7/8/2021

photobleaching

Very satisfied with the experimental data! Nonoxynol-5 has good absorption at 350-500 nm, rapidly photolyzes under the irradiation of LED visible light, has photobleaching properties, and can be further applied to DLP 3D printing to construct three-dimensional light-emitting structures with high precision.

19/3/2016

luminescent cluster

The quality of the product is acceptable. A novel cyanofluorescence probe withNonoxynol-5 chalcone structure as the luminescent cluster and a co-lingual C=C bond as the reaction site was constructed, which has high selectivity and sensitivity for CN recognition, and can be used as a ratiometric fluorescent probe for naked-eye and efficient detection of CN.

10/9/2016

minimum inhibitory concentration

Nonoxynol-5 has significant inhibitory effect on Escherichia coli, Enterobacter aerogenes, Salmonella typhi, Streptococcus pneumoniae and Staphylococcus aureus, the minimum inhibitory concentration (MIC) is 79, 73 umolL respectively.

7/2/2022

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂