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t-Boc-N-amido-PEG2-bromide - CAS 165963-71-3

Inquiry

t-Boc-N-amido-PEG2-bromide is a PEG linker containing a bromide group and a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

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Molecular Formula

C11H22BrNO4

Molecular Weight

312.20

t-Boc-N-amido-PEG2-bromide

- Specification
  - Purity
    
    ≥95%
    
    Solubility
    
    Soluble in Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
    
    Appearance
    
    Pale Yellow Oily Matter
    
    Application
    
    A cross-linking reagent.
    
    Shelf Life
    
    -20°C 3 years powder; -80°C 2 years in solvent
    
    Storage
    
    Store at -20°C under inert atmosphere
    
    Shipping
    
    Room temperature, or blue ice upon request.
    
    IUPAC Name
    
    tert-butyl N-[2-[2-(2-bromoethoxy)ethoxy]ethyl]carbamate
    
    Synonyms
    
    Br-PEG2-NHBoc; Boc-NH-PEG2-Br; BocNH-PEG2-CH2CH2Br; N-Boc-PEG2-bromide; tert-Butyl (2-(2-(2-bromoethoxy)ethoxy)ethyl)carbamate; 2-[2-(2-t-Boc-aminoethoxy]ethoxy]ethyl Bromide; N-[2-[2-(2-Bromoethoxy)ethoxy]ethyl]carbamic Acid 1,1-Dimethylethyl Ester; 2-[2-[2-(tert-Butoxycarbonylamino)ethoxy]ethoxy]ethyl Bromide; Carbamic acid, N-[2-[2-(2-bromoethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester; N-Boc-2-[2-(2-bromoethoxy)ethoxy]ethanamine; 2-Methyl-2-propanyl {2-[2-(2-bromoethoxy)ethoxy]ethyl}carbamate
- Properties
  - Boiling Point
    
    382.8±27.0°C (Predicted)
    
    Density
    
    1.257±0.06 g/cm3 (Predicted)
    
    InChI Key
    
    WGWDCMKAMHBDPO-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C11H22BrNO4/c1-11(2,3)17-10(14)13-5-7-16-9-8-15-6-4-12/h4-9H2,1-3H3,(H,13,14)
    
    Canonical SMILES
    
    CC(C)(C)OC(=O)NCCOCCOCCBr
    
    Biological Activity
    
    N-Boc-PEG3-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

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