Name: m-PEG4-(CH2)6-Phosphonic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

8-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]octylphosphonic acid

Synonyms

m-PEG4-(CH2)8-Phosphonic acid; (2,5,8,11-Tetraoxanonadecan-19-yl)phosphonic acid; Phosphonic acid, P-9,12,15,18-tetraoxanonadec-1-yl-; 2,5,8,11-Tetraoxanonadecan-19-ylphosphonic acid; Phosphonic acid, 9,12,15,18-tetraoxanonadec-1-yl-

Boiling Point

487.2±55.0°C at 760 mmHg

Density

1.1±0.1 g/cm3

InChI Key

JNQSHEHZCLMYKY-UHFFFAOYSA-N

InChI

InChI=1S/C15H33O7P/c1-19-9-10-21-13-14-22-12-11-20-8-6-4-2-3-5-7-15-23(16,17)18/h2-15H2,1H3,(H2,16,17,18)

SMILES

COCCOCCOCCOCCCCCCCCP(=O)(O)O

m-PEG4-(CH2)6-Phosphonic acid is a versatile linker building block designed to support targeted protein degradation (PROTAC) workflows by providing a hydrophilic PEG segment and a flexible aliphatic tether that can be tuned for productive ternary complex formation. Its phosphonic acid functionality enables robust chemical handle(s) for conjugation strategies commonly used to assemble PROTAC constructs. The detailed structural and reactivity considerations below describe how this linker’s features can be leveraged during PROTAC synthesis and characterization.

Structure: The linker contains a PEG-derived polyether chain and a saturated hexamethylene spacer that impart conformational flexibility and aqueous compatibility. A phosphonic acid group provides a strongly polar, hydrogen-bonding functionality, while aromatic substitution patterns contribute defined aromatic character and stable covalent connectivity.

Reactivity: Phosphonic acids can participate in coupling and derivatization routes such as activation to form reactive phosphorus intermediates for amide- or ester-type bond formation, or for attachment to complementary functional groups on ligands used in PROTACs. Typical conditions employ dry, inert or controlled aqueous/organic solvent systems, with base and dehydrating or activating reagents chosen to minimize phosphonate hydrolysis and preserve linker integrity.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂