Thalidomide-5-O-CH2-COOH

 CAS No.: 2467425-53-0  Cat No.: BP-100184 4.5  

Thalidomide-5-O-CH2-COOH is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide and NH-PEG3-NH-Boc. It acts as a ligand for Cereblon to recruit CRBN protein.

Thalidomide-5-O-CH2-COOH

Structure of 2467425-53-0

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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C15H12N2O7
Molecular Weight
332.26

* For research and manufacturing use only. Not for human or clinical use.

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Synonyms
Acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]oxy]-; 2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]oxy}acetic acid
InChI Key
DTZXDGPVNFRIOU-UHFFFAOYSA-N
InChI
InChI=1S/C15H12N2O7/c18-11-4-3-10(13(21)16-11)17-14(22)8-2-1-7(24-6-12(19)20)5-9(8)15(17)23/h1-2,5,10H,3-4,6H2,(H,19,20)(H,16,18,21)
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCC(=O)O

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It is commonly abbreviated as: C1V1 = C2V2

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Historical Records: cIAP1 Ligand-Linker Conjugates 7 | (S,R,S)-AHPC-C10-NH2 dihydrochloride | cIAP1 Ligand-Linker Conjugates 4 | (S,R,S)-AHPC-PEG4-Alkyne | Thalidomide-O-amido-C6-NH2 hydrochloride | VH032-thiol-C6-NH2 | Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride | Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride | (S,R,S)-AHPC-PEG5-COOH | Thalidomide-O-C6-COOH

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