DBCO-Biotin
CAS No.: 1418217-95-4
Cat No.: BP-501698
4.5 
DBCO-Biotin is a biotin conjugate bearing a cyclooctyne (DBCO) functional group, providing a strained-alkyne handle for rapid, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC). Structurally, it consists of a biotin scaffold linked to DBCO through a defined linker, yielding a compact, modular reagent with a single reactive cyclooctyne moiety. In PROTAC and targeted degradation workflows, DBCO-Biotin is valuable as a conjugation partner to install biotin tags on ligands, linkers, or carrier components, enabling subsequent affinity-based enrichment (e.g., streptavidin capture) and facilitating controlled assembly of multicomponent constructs. The SPAAC reaction allows orthogonal attachment to azide-functionalized PROTAC elements under mild conditions, minimizing degradation of sensitive binding motifs. Overall, it supports efficient synthesis, purification, and mechanistic studies of targeted protein degradation systems by improving traceability and handling of conjugates.
Structure of 1418217-95-4
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DBCO-Biotin is a bifunctional, click-reactive linker designed for modular PROTAC assembly and for integrating biotin-tagged affinity handles into targeted protein degradation workflows. Its strained cyclooctyne core enables efficient bioorthogonal conjugation with azide-bearing ligands under mild conditions, supporting rapid construction of degraders and related conjugates. The following sections describe the linker’s structural attributes and practical reactivity considerations in PROTAC-relevant synthesis.
Structure: DBCO-Biotin contains a dibenzocyclooctyne (DBCO) moiety coupled to a biotin-derived scaffold. It features a strained alkyne suitable for strain-promoted azide–alkyne cycloaddition, along with amide and heteroatom-rich functional groups that support aqueous compatibility and stable conjugate formation.
Reactivity: DBCO-Biotin is used in strain-promoted azide–alkyne cycloaddition with azide-functional partners, typically proceeding without added copper. Suitable conditions include neutral to mildly basic aqueous or mixed solvent systems that preserve azide integrity and maintain solubility. The reaction follows a cycloaddition mechanism driven by ring strain, and conjugation is commonly monitored by analytical methods such as chromatography or mass spectrometry; catalysts are generally unnecessary for copper-free operation.
Can DBCO-Biotin be discussed as a research-grade intermediate?
Yes. It can be discussed as a research-grade intermediate for fine chemical, and research work, especially where the project needs a defined structure for synthesis screening or sourcing evaluation. The final quotation should be based on current availability, quality requirements, and requested quantity.
14/09/2025
Is COA or SDS available for this product?
COA, SDS, or other analytical documentation may be available depending on batch availability and project requirements. Please contact us to confirm the available documents.
06/04/2025
Can this product be supplied in different quantities?
Package size and supply scale can be discussed based on current availability, production schedule, and project requirements. Please submit your required quantity for evaluation.
27/12/2023
Can I request a quote for DBCO-Biotin?
Yes. Please submit the product name, CAS number, required quantity, desired purity, destination country, and expected timeline so that availability and quotation details can be reviewed.
16/11/2023
What documentation should be discussed for DBCO-Biotin orders?
Depending on batch availability and project requirements, documentation may include COA, SDS, chromatographic data, or other analytical information. Please specify which documents are needed for internal review, import clearance, or project qualification when submitting the inquiry.
12/04/2022
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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