Ald-Ph-PEG24-TFP ester
Cat No.: BP-501886
4.5 
Ald-Ph-PEG24-TFP ester is a heterobifunctional PEG-based linker featuring an aldehyde handle and a phenyl spacer that connects to a terminal tetrafluorophenyl (TFP) ester, providing two orthogonal conjugation chemistries. The aldehyde group enables formation of reversible imine (Schiff base) linkages with primary amines, while the TFP ester efficiently reacts with lysine residues or amino-functional groups to form stable amide bonds under standard bioconjugation conditions. In PROTAC and targeted degradation workflows, this linker can be used to assemble degraders by attaching one ligand (e.g., an E3-recruiting or target-binding moiety) through amide coupling at the TFP ester, and then installing the second component via aldehyde–amine chemistry, allowing controlled spatial separation and improved productive ternary complex formation. Its long PEG chain supports aqueous solubility and reduces steric constraints, making it valuable for optimizing linker length and attachment geometry in experimental targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Ald-Ph-PEG24-TFP ester is a PEG-based bifunctional linker designed for constructing PROTACs through efficient conjugation to primary amines and subsequent attachment to aldehyde-bearing payloads. Its PEG scaffold provides conformational flexibility and improved solubility, while the TFP ester offers a highly reactive acylating handle for rapid, controlled coupling. This product is well suited for assembling targeted protein degraders by enabling modular synthesis of PROTAC intermediates, as detailed in the sections below.
Structure: The linker contains a PEG chain segment connected to an aromatic phenyl group and terminated with an aldehyde functionality and a TFP (tetrafluorophenyl) ester. It features ether linkages within the PEG backbone, an aldehyde carbonyl, and an activated carboxylate ester, supporting aqueous compatibility and stable handling.
Reactivity: The TFP ester undergoes nucleophilic acyl substitution with primary amines under mildly basic aqueous or mixed solvent conditions to form stable amide bonds, typically without requiring specialized catalysts. Reaction progress is commonly monitored by analytical methods, and excess amine is used to drive coupling. The aldehyde functionality can be preserved for downstream chemistries such as reversible imine formation or subsequent reductive amination, depending on the PROTAC design.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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