Thalidomide-O-C5-acid - CAS 2087490-48-8

Thalidomide-O-C5-acid is a synthetic E3 ligand-linker conjugate containing a cereblon ligand based on Thalidomide and an alkyl linker with a terminal carboxylic acid, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand..

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Molecular Formula
C₁₉H₂₀N₂O₇
Molecular Weight
388.37

Thalidomide-O-C5-acid

    • Specification
      • Solubility
        In DMSO: 250 mg/mL (643.72 mM; Need ultrasonic)
        Storage
        4°C, protect from light, stored under nitrogen; In solvent, -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
        Shipping
        Room temperature in continental US; may vary elsewhere.
        IUPAC Name
        6-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyhexanoic acid
    • Properties
      • InChI Key
        PBZGPWVWKSADLD-UHFFFAOYSA-N
        InChI
        1S/C19H20N2O7/c22-14-9-8-12(17(25)20-14)21-18(26)11-5-4-6-13(16(11)19(21)27)28-10-3-1-2-7-15(23)24/h4-6,12H,1-3,7-10H2,(H,23,24)(H,20,22,25)
        Canonical SMILES
        OC(CCCCCOC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O
        Pub Chem ID
        132212109
Bio Calculators
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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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