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Amino-PEG2-t-butyl ester - CAS 756525-95-8

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NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Molecular Formula
C11H23NO4
Molecular Weight
233.30

Amino-PEG2-t-butyl ester

    • Specification
      • Purity
        > 98.0 %
        Solubility
        10 mm in DMSO
        Appearance
        Colorless to light yellow clear liquid
        Storage
        Store at -5 ℃, keep in dry and avoid sunlight.
        Shipping
        Room temperature, or blue ice upon request.
        IUPAC Name
        tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
        Synonyms
        Amino-PEG2-COOtBu; H2N-PEG2-CH2CH2COOtBu; tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
    • Properties
      • Boiling Point
        313.7±22.0 °C at 760 mmHg
        Density
        1.0±0.1 g/cm3
        InChI Key
        XIVHGTLMLORWEP-UHFFFAOYSA-N
        InChI
        InChI=1S/C11H23NO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9,12H2,1-3H3
        Canonical SMILES
        CC(C)(C)OC(=O)CCOCCOCCN
        Biological Activity
        NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] . ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]
Bio Calculators
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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
g
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