Benzyl-PEG24-alcohol
CAS No.: 2218463-19-3
Cat No.: BP-501437
Purity: >95%
4.5 
Benzyl-PEG24-alcohol is a polyethylene glycol (PEG) linker bearing a benzyl group at one terminus and a terminal primary alcohol at the other, providing a long, flexible, hydrophilic chain suitable for conjugation chemistry. In PROTAC and targeted protein degradation constructs, such PEG linkers are widely used to tune the spatial relationship between the ligand that recruits an E3 ligase and the ligand that binds the target protein, thereby improving productive ternary complex formation while reducing steric clashes. The extended PEG segment can enhance solubility and help maintain favorable conformational freedom, which is critical for efficient ubiquitination and subsequent proteasomal degradation. The benzyl end group serves as a chemically addressable handle for downstream functionalization, while the alcohol enables straightforward derivatization (e.g., esterification or activation for coupling) to attach the linker to other PROTAC modules. This product is valuable for researchers optimizing linker length and attachment points to achieve robust, reproducible degradation phenotypes.
Structure of 2218463-19-3
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Benzyl-PEG24-alcohol is a polyethylene glycol (PEG)-based linker building block tailored for constructing PROTACs and other targeted protein degradation conjugates. Its flexible PEG chain supports productive ternary-complex formation by improving solubility and reducing steric constraints around the ligation handle. The benzyl-terminated alcohol functionality enables reliable functionalization strategies to connect protein-binding warheads while maintaining linker adaptability. Detailed structural and reactivity considerations are provided below.
Structure: The molecule features a benzyl end group connected to a long, repeating PEG ether chain terminating in a primary alcohol. Its backbone is dominated by ether linkages, providing conformational flexibility, while the terminal hydroxyl offers a polar, hydrogen-bonding functional site for derivatization.
Reactivity: The terminal alcohol can be converted into PROTAC-compatible electrophiles or activated intermediates using standard organic functional-group transformations. Typical approaches include alcohol activation followed by nucleophilic substitution or coupling to install the attachment point for E3-ligase and target-binding moieties. Mild bases and common coupling reagents are often used, with polar aprotic solvents frequently improving solubility and reaction efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
