PROTAC Sirt2 Degrader-1

 CAS No.: 2098487-75-1  Cat No.: BP-400049 4.5  

PROTAC Sirt2 Degrader-1 is a PROTAC selectively targeting on Sirt2, consist an isotype-selective Sirt2 inhibitor SirReal as a warhead linked to cereblon ligand thalidomide. PROTAC Sirt2 Degrader-1 led a selective and dose-dependent degradation of Sirt2 at concentration ranging in 0.2-5μM, as well as a time-dependent depletion of Sirt2 at concentration of 10μM post 0.5-2h with a max degradation observed at 2h in HeLa cells. Depletion of Sirt2 by PROTAC Sirt2 Degrader-1 at concentration of 10μM resulted in a more pronounced acetylation of the microtubule network with enhanced process elongation than enzymatic Sirt2 inhibition.

PROTAC Sirt2 Degrader-1

Structure of 2098487-75-1

Quality
Assurance

Worldwide
Delivery

24/7 Customer
Support
Category
PROTAC
Molecular Formula
C40H40N10O8S2
Molecular Weight
852.94

* For research and manufacturing use only. Not for human or clinical use.

SizePriceStockQuantity
-- $-- In stock

Looking for different specifications? Click to request a custom quote!

Capabilities & Facilities

  • mg to g scale for early stage;
  • CDMO and CMO support.
  • 24/7 customer service;
  • 100% quality assurance;
  • Efficient global delivery;
  • Over 95% customer satisfaction.
Popular Publications Citing BOC Sciences Products
Solubility
Soluble in DMSO
Storage
Powder<br/>-20°C<br/>3 years<br/><br/><br/>In solvent<br/>-80°C<br/>6 months<br/><br/><br/> <br/>-20°C<br/> 1 month
Shipping
Room temperature in continental US; may vary elsewhere
Synonyms
Sirt2-PROTAC-1; Sirt2 PROTAC-1; Sirt2-PROTAC1; Sirt2 PROTAC 1; N-[4-[4-[[3-[[2-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]-1,3-thiazol-5-yl]methyl]phenoxy]methyl]triazol-1-yl]butyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
InChI Key
GRYRXFYWVDWPQY-UHFFFAOYSA-N
InChI
InChI=1S/C40H40N10O8S2/c1-23-15-24(2)44-40(43-23)59-22-34(53)46-39-42-18-28(60-39)17-25-7-5-8-27(16-25)57-20-26-19-49(48-47-26)14-4-3-13-41-33(52)21-58-31-10-6-9-29-35(31)38(56)50(37(29)55)30-11-12-32(51)45-36(30)54/h5-10,15-16,18-19,30H,3-4,11-14,17,20-22H2,1-2H3,(H,41,52)(H,42,46,53)(H,45,51,54)
Canonical SMILES
CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C

Stock concentration: *
Desired final volume: *
Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

Calculate
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
g
Historical Records: FKBP12 PROTAC dTAG-13 | PROTAC Sirt2 Degrader-1 | PROTAC BET degrader-2 | 3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione | AVL-292 | PROTAC B-Raf degrader 1 | PROTAC CDK9 Degrader-1

Related Product Recommendations

In Stock Purity: 0.98 Hot
Nexturastat A
Nexturastat A

CAS: 1403783-31-2
In Stock Purity: >95% Hot
Triethylene Glycol Mono(2-propynyl) Ether
Triethylene Glycol Mono(2-propynyl) Ether

CAS: 208827-90-1
In Stock Purity: ≥95% Hot
Propargyl-PEG5-acid
Propargyl-PEG5-acid

CAS: 1245823-51-1
In Stock Hot
Ribociclib
Ribociclib

CAS: 1211441-98-3
In Stock Purity: 95% Hot
Propargyl-PEG2-Tos
Propargyl-PEG2-Tos

CAS: 145916-41-2
In Stock Purity: 95% Hot
DOTA-PEG5-azide
DOTA-PEG5-azide
BOC Sciences Support

Please contact us with any specific requirements and we will get back to you as soon as possible.


  • Verification code

We invite you to contact us at or through our contact form above for more information about our services and products.

USA
  • International:
  • US & Canada (Toll free):
  • Email:
  • Fax:
UK
Germany
Copyright © 2025 BOC Sciences. All Rights Reserved.
Inquiry Basket
Loading......
Delete selected Go to checkout