Name: PROTAC Sirt2 Degrader-1
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Solubility

Soluble in DMSO

Storage

Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month

Shipping

Room temperature in continental US; may vary elsewhere

Synonyms

Sirt2-PROTAC-1; Sirt2 PROTAC-1; Sirt2-PROTAC1; Sirt2 PROTAC 1; N-[4-[4-[[3-[[2-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]-1,3-thiazol-5-yl]methyl]phenoxy]methyl]triazol-1-yl]butyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide

InChI Key

GRYRXFYWVDWPQY-UHFFFAOYSA-N

InChI

InChI=1S/C40H40N10O8S2/c1-23-15-24(2)44-40(43-23)59-22-34(53)46-39-42-18-28(60-39)17-25-7-5-8-27(16-25)57-20-26-19-49(48-47-26)14-4-3-13-41-33(52)21-58-31-10-6-9-29-35(31)38(56)50(37(29)55)30-11-12-32(51)45-36(30)54/h5-10,15-16,18-19,30H,3-4,11-14,17,20-22H2,1-2H3,(H,41,52)(H,42,46,53)(H,45,51,54)

SMILES

CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C

Mechanism

Target: Targets SIRT2 NAD-dependent deacetylase for experimental targeted protein degradation studies.

Binding Site: Binds the SIRT2 catalytic pocket and recruited E3 ligase ligand site to support productive ternary complex formation.

Mechanism of Action: PROTAC Sirt2 Degrader-1 is designed for use in PROTAC or targeted protein degradation experiments directed toward SIRT2 NAD-dependent deacetylase. The bifunctional molecule links a target-recognition element to cereblon, promoting proximity between the protein of interest and ubiquitination machinery. Productive ternary-complex formation can drive polyubiquitination and proteasome-dependent target depletion, allowing researchers to compare pharmacological inhibition with protein removal. It is suitable for evaluating degradation potency, kinetics, pathway selectivity, and downstream signaling consequences in engineered or disease-relevant cellular models.

Applications

• PROTAC-Mediated Sirt2 Degradation: PROTAC Sirt2 Degrader-1 is designed for the selective degradation of Sirt2, a member of the sirtuin family of NAD+-dependent deacetylases. This application is crucial for studying Sirt2's role in cellular processes such as aging, metabolism, and neurodegeneration, providing insights into Sirt2's functional impact through targeted protein degradation.

• Neurodegenerative Disease Research: Utilizing PROTAC Sirt2 Degrader-1 allows researchers to explore the therapeutic potential of Sirt2 degradation in neurodegenerative diseases. By facilitating the removal of Sirt2, scientists can investigate its involvement in pathological pathways, potentially identifying new avenues for therapeutic intervention in diseases like Alzheimer's and Parkinson's.

• Metabolic Pathway Analysis: This PROTAC serves as a valuable tool for dissecting metabolic pathways influenced by Sirt2. By enabling targeted degradation, researchers can assess the downstream effects of Sirt2 removal, advancing the understanding of metabolic regulation and its implications in conditions such as obesity and diabetes.

• Aging and Longevity Studies: PROTAC Sirt2 Degrader-1 is instrumental in aging research, allowing for the exploration of Sirt2's contribution to longevity and age-related cellular changes. By degrading Sirt2, scientists can study its impact on lifespan and age-associated diseases, potentially uncovering targets for promoting healthy aging.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂