Amino-PEG2-t-butyl ester

 CAS No.: 756525-95-8  Cat No.: BP-500123  Purity: > 98.0 % 4.5  

NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Amino-PEG2-t-butyl ester

Structure of 756525-95-8

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Category
PROTAC Linker
Molecular Formula
C11H23NO4
Molecular Weight
233.30
Appearance
Colorless to light yellow clear liquid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
> 98.0 %
Solubility
10 mm in DMSO
Appearance
Colorless to light yellow clear liquid
Storage
Store at -5 °C, keep in dry and avoid sunlight.
Shipping
Room temperature, or blue ice upon request.
IUPACName
tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
Synonyms
Amino-PEG2-COOtBu; H2N-PEG2-CH2CH2COOtBu; tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
Boiling Point
313.7±22.0 °C at 760 mmHg
Density
1.0±0.1 g/cm3
InChI Key
XIVHGTLMLORWEP-UHFFFAOYSA-N
InChI
InChI=1S/C11H23NO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9,12H2,1-3H3
Canonical SMILES
CC(C)(C)OC(=O)CCOCCOCCN
Biological Activity
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] . ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: Chloroacetamido-PEG4-NHS ester | Amino-PEG7-amine | Amino-PEG3-C2-sulfonic acid | Amino-PEG9-amine | Tr-PEG4-OH | Azido-PEG10-alcohol | Tetraethylene glycol monotosylate | Boc-PEG4-acid | Fmoc-N-amido-PEG12-acetic acid | MZ2 | Amino-PEG2-t-butyl ester

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