Name: GNE-8525
Brand: BOC Sciences
Price: 838 USD
Availability: MadeToOrder

Size

Price

Stock

Quantity

50 mg

$838

In stock

Purity

98%

Solubility

Soluble in DMSO

Appearance

Powder

Application

antitumor

ShelfLife

2 month in rt, long time

Storage

-20°C Freezer

IUPACName

1-[4-[6-[6-[2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]pyridin-2-yl]piperidin-4-ol

Synonyms

GNF-8625; GNF 8625; GNF8625. (R)-1-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-[2,4'-bipyridin]-2'-yl)piperidin-4-ol

InChI Key

BLGCSOKKBWHJMB-UHFFFAOYSA-N

InChI

InChI=1S/C31H30FN7O/c32-23-5-1-4-22(18-23)27-8-3-15-38(27)30-10-9-29-34-20-28(39(29)36-30)26-7-2-6-25(35-26)21-11-14-33-31(19-21)37-16-12-24(40)13-17-37/h1-2,4-7,9-11,14,18-20,24,27,40H,3,8,12-13,15-17H2

Canonical SMILES

C1CC(N(C1)C2=NN3C(=NC=C3C4=CC=CC(=N4)C5=CC(=NC=C5)N6CCC(CC6)O)C=C2)C7=CC(=CC=C7)F

HPLC

HNMR

What is the pharmacokinetics of GNE-8525?

GNE-8525 exhibits moderate in vivo plasma clearances, moderate volumes of distribution, short half-lives, and brain penetration.

27/1/2016

What is the activity of GNE-8525 in vitro?

GNE-8525 has kinase selectivity for MKK4, MKK7, JNK1, JNK2, JNK3, MLK1, MLK2 and MLK3 with IC50 values of >5000 nM, >5000 nM, 129 nM, 514 nM, 364 nM, 67.8 nM, 767 nM and 602 nM, respectively.

20/6/2016

GNE-8525 suppresse CYP-induced nociceptive behavior?

GNE-8525 suppresses CYP-induced nociceptive behavior by inhibiting DLK in mice.

6/12/2018

suppresses CYP-induced edema and hemorrhage

GNE-8525 do well in suppressing CYP-induced edema and hemorrhage in mouse bladder. Very useful for our study!

8/1/2019

display concentration-dependent protection of neurons from degeneration

GNE-8525 displays concentration-dependent protection of neurons from degeneration in vitro. Satisfied with product.

21/12/2021

Stock concentration: *

Desired final volume: *

Desired concentration: *

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂