Name: Biotin-PEG4-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>97%

Appearance

White powder

Storage

Powder, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[2-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

3-[2-[2-[2-[2-[[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid; 3-[2-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Boiling Point

784.8±60.0 °C at 760 mmHg

Density

1.2±0.1 g/cm3

InChI Key

GYOXFFWLRKVJJX-ZWOKBUDYSA-N

InChI

InChI=1S/C21H37N3O8S/c25-18(4-2-1-3-17-20-16(15-33-17)23-21(28)24-20)22-6-8-30-10-12-32-14-13-31-11-9-29-7-5-19(26)27/h16-17,20H,1-15H2,(H,22,25)(H,26,27)(H2,23,24,28)/t16-,17-,20-/m0/s1

SMILES

C1C2C(C(S1)CCCCC(=O)NCCOCCOCCOCCOCCC(=O)O)NC(=O)N2

Biotin-PEG4-propionic acid is a versatile PROTAC linker building block that combines a biotin recognition handle with a hydrophilic polyethylene glycol spacer and a carboxylic acid for controlled conjugation. Its flexible, water-compatible architecture supports efficient tethering and can improve solubility and bioconjugation performance in targeted protein degradation workflows. The following sections describe its structure and practical reactivity considerations in detail.

Structure: The linker features a biotin moiety connected through a polyethylene glycol spacer to a terminal propionic acid functionality. It contains amide and ether linkages typical of PEG-based conjugates, with multiple heteroatoms that enable hydrogen bonding. The resulting molecule is generally water-compatible and conformationally flexible.

Reactivity: The terminal carboxylic acid is suitable for standard PROTAC assembly strategies that form amide or ester bonds with complementary nucleophiles on warheads or E3 ligands. Common approaches include activation of the acid using carbodiimide coupling systems and subsequent reaction with amine-bearing partners under mild, aqueous or mixed-solvent conditions. Reaction efficiency is typically improved by controlling pH and minimizing hydrolysis of activated intermediates.

Stock concentration: *

Desired final volume: *

Desired concentration: *

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂