m-PEG15-amine
Cat No.: BP-501815
4.5 
m-PEG15-amine is a methoxy-terminated polyethylene glycol linker bearing a primary amine at the distal end, providing a flexible, water-soluble chain of intermediate length suitable for bioconjugation chemistry. Structurally, the PEG segment acts as a hydrophilic spacer that improves solubility, reduces nonspecific adsorption, and can mitigate steric interference between a targeting ligand and an E3-recruiting or warhead moiety. The terminal amine enables covalent attachment to activated carboxylates, activated esters, isothiocyanates, or other electrophilic coupling partners, allowing researchers to incorporate the linker into PROTAC architectures where controlled spacing and conjugation geometry are critical for productive ternary complex formation and efficient ubiquitin–proteasome pathway engagement. In targeted protein degradation research, such PEG linkers are widely used to tune linker length and polarity, thereby supporting systematic optimization of degradation potency, selectivity, and experimental handling for in vitro and cellular assays.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG15-amine is a polyethylene glycol (PEG)-based amine linker designed to support the modular synthesis of PROTACs by providing a hydrophilic spacer and a functional handle for conjugation. Its ether-rich backbone can improve solubility and presentation of binding motifs, while the terminal primary amine enables robust coupling strategies to install warheads or E3 ligase ligands. The detailed structural and reactivity considerations for PROTAC assembly are provided below.
Structure: The linker consists of a linear PEG chain terminated by a primary amine, featuring repeating ether (C–O–C) units that confer flexibility and strong hydrogen-bonding capacity. The molecule contains an amine for nucleophilic chemistry and an ether-rich scaffold that enhances aqueous compatibility.
Reactivity: The terminal primary amine is suitable for amide bond formation via activated carboxylic acids (e.g., using common coupling reagents) or for forming urea/related linkages with carbonyl-activated electrophiles. Typical PROTAC linker conjugations are performed under inert or controlled conditions in polar aprotic solvents, with base to promote nucleophilicity and minimize side reactions, following standard amine–electrophile coupling principles.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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