Name: Pomalidomide-C4-NH2
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Appearance

White to Off-white Solid

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

IUPACName

4-(4-aminobutylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

Synonyms

4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-; Thalidomide-NH-C4-NH2

Boiling Point

641.4±55.0°C at 760 mmHg

Density

1.4±0.1 g/cm3

InChI Key

KMGOFKGAYSFPGS-UHFFFAOYSA-N

InChI

InChI=1S/C17H20N4O4/c18-8-1-2-9-19-11-5-3-4-10-14(11)17(25)21(16(10)24)12-6-7-13(22)20-15(12)23/h3-5,12,19H,1-2,6-9,18H2,(H,20,22,23)

Canonical SMILES

C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCN

Background Introduction

Pomalidomide-C4-NH2 is a specialized E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. Combining pomalidomide, a thalidomide analog known for its high binding affinity to the cereblon (CRBN) E3 ubiquitin ligase, with a tailored C4 amine-terminated linker, this compound is optimized for PROTAC (Proteolysis Targeting Chimera) synthesis. The presence of the reactive amine group enables flexible conjugation to a variety of target protein ligands, facilitating the development of novel protein degradation tools and drug discovery processes.

Mechanism

Pomalidomide-C4-NH2 operates as a bifunctional molecule where the pomalidomide moiety binds to the CRBN E3 ubiquitin ligase. The C4 linker provides spatial separation and flexibility, while the terminal NH2 (amine) group serves as a convenient point for covalent attachment to target protein ligands or functional groups. When incorporated into a PROTAC construct, pomalidomide-C4-NH2 binds CRBN, brings it in proximity to the chosen protein of interest, and promotes ubiquitination. This process targets the protein for proteasomal degradation, thereby selectively reducing its levels within the cell.

Applications

Pomalidomide-C4-NH2 is a key building block for the synthesis of CRBN-based PROTACs. Its applications include the development of research tools for targeted protein degradation, validation of new drug targets, and preclinical evaluation of novel therapeutics. This conjugate is widely used by medicinal chemists and researchers designing heterobifunctional degraders for oncology, neurodegenerative disorders, and other disease models. It offers versatility in PROTAC assembly, platform flexibility, and precise control for selective protein knockdown studies in cellular and in vivo contexts.

• Amine-functionalized C4 linker enables versatile conjugation to various warheads or payloads for PROTAC design.
• Ideal for selective recruitment of CRBN E3 ligase, supporting efficient targeted protein degradation research.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂