Bis-PEG6-NHS ester

≥95%

Soluble in DCM, DMSO

Pale Yellow or Colorless Oily Matter

-20°C 3 years powder; -80°C 2 years in solvent

Store at 2-8°C

Room temperature

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

NHS-PEG6-NHS; 4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester; Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate; Di-NHS Ester-PEG6; 1,1'-[(1,22-Dioxo-4,7,10,13,16,19-hexaoxadocosane-1,22-diyl)bis(oxy)]di(2,5-pyrrolidinedione); 2,5-Pyrrolidinedione, 1,1'-[(1,22-dioxo-4,7,10,13,16,19-hexaoxadocosane-1,22-diyl)bis(oxy)]bis-

659.4±65.0°C at 760 mmHg

1.4±0.1 g/cm3

FDLGRFGWAMAWTE-UHFFFAOYSA-N

InChI=1S/C24H36N2O14/c27-19-1-2-20(28)25(19)39-23(31)5-7-33-9-11-35-13-15-37-17-18-38-16-14-36-12-10-34-8-6-24(32)40-26-21(29)3-4-22(26)30/h1-18H2

C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O

Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.