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Bis-PEG6-NHS ester - CAS 1526718-98-8

Inquiry

Bis-PEG6-NHS ester is a non-cleavable 6-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).

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Molecular Formula

C24H36N2O14

Molecular Weight

576.55

Bis-PEG6-NHS ester

- Specification
  - Related CAS
    
    123502-57-8 (polymer)
    
    Purity
    
    ≥95%
    
    Solubility
    
    Soluble in DCM, DMSO
    
    Appearance
    
    Pale Yellow or Colorless Oily Matter
    
    Shelf Life
    
    -20°C 3 years powder; -80°C 2 years in solvent
    
    Storage
    
    Store at 2-8°C
    
    Shipping
    
    Room temperature
    
    IUPAC Name
    
    (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
    
    Synonyms
    
    NHS-PEG6-NHS; 4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester; Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate; Di-NHS Ester-PEG6; 1,1'-[(1,22-Dioxo-4,7,10,13,16,19-hexaoxadocosane-1,22-diyl)bis(oxy)]di(2,5-pyrrolidinedione); 2,5-Pyrrolidinedione, 1,1'-[(1,22-dioxo-4,7,10,13,16,19-hexaoxadocosane-1,22-diyl)bis(oxy)]bis-
- Properties
  - Boiling Point
    
    659.4±65.0°C at 760 mmHg
    
    Density
    
    1.4±0.1 g/cm3
    
    InChI Key
    
    FDLGRFGWAMAWTE-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C24H36N2O14/c27-19-1-2-20(28)25(19)39-23(31)5-7-33-9-11-35-13-15-37-17-18-38-16-14-36-12-10-34-8-6-24(32)40-26-21(29)3-4-22(26)30/h1-18H2
    
    Canonical SMILES
    
    C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O
    
    Biological Activity
    
    Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
- Preparing Stock Solutions
  - ConcentrationVolumeMass 1 mg 5 mg 10 mg
    
    1 mM 1.7345 mL 8.6723 mL 17.3445 mL
    
    5 mM 0.3469 mL 1.7345 mL 3.4689 mL
    
    10 mM 0.1734 mL 0.8672 mL 1.7345 mL

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	1.7345 mL	8.6723 mL	17.3445 mL
5 mM	0.3469 mL	1.7345 mL	3.4689 mL
10 mM	0.1734 mL	0.8672 mL	1.7345 mL

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