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SPDP-PEG8-COOH - CAS 1334177-96-6

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SPDP-PEG8-COOH is a PEG-based PROTAC linker which is applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. It contains SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward amine and thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and DCC to form stable amide bonds. The water solubility properties of PEG linkers is enhanced by longer PEG chains.

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Molecular Formula

C27H46N2O11S2

Molecular Weight

638.79

SPDP-PEG8-COOH

- Specification
  - Purity
    
    ≥95%
    
    Solubility
    
    Soluble in DMSO
    
    Appearance
    
    Light Yellow or White Solid
    
    Storage
    
    Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
    
    Shipping
    
    Room temperature in continental US; may vary elsewhere.
    
    IUPAC Name
    
    3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
    
    Synonyms
    
    SPDP-PEG8-acid; OPSS-PEG8-COOH; 3-oxo-1-(pyridin-2-yldisulfanyl)-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid; alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-carboxy octa(ethylene glycol)
- Properties
  - Boiling Point
    
    768.5±60.0 °C at 760 mmHg
    
    Density
    
    1.2±0.1 g/cm3
    
    InChI Key
    
    DKWMKNTUPXBDLZ-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C27H46N2O11S2/c30-25(5-24-41-42-26-3-1-2-6-29-26)28-7-9-34-11-13-36-15-17-38-19-21-40-23-22-39-20-18-37-16-14-35-12-10-33-8-4-27(31)32/h1-3,6H,4-5,7-24H2,(H,28,30)(H,31,32)
    
    Canonical SMILES
    
    C1=CC=NC(=C1)SSCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

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