1,14-Dichloro-3,6,9,12-tetraoxatetradecane
CAS No.: 5197-65-9
Cat No.: BP-500302
Purity: 98%
4.5 
1,14-Dichloro-3,6,9,12-tetraoxatetradecane is a halogenated, poly(ethylene glycol)-like linker featuring two terminal chloro leaving groups separated by a tetraether oxygen-rich chain. Structurally, it provides a flexible, hydrophilic spacer that can be used to connect PROTAC building blocks through nucleophilic substitution at the chloro termini, enabling the installation of two functional handles for conjugation to ligands or warheads. In PROTAC design, such oxygenated linkers help tune the effective distance and relative orientation between the target-binding moiety and the E3 ligase recruiter, often improving productive ternary complex formation while reducing steric strain. Its defined bifunctionality supports modular synthesis of degraders and facilitates systematic structure–activity studies, where linker length, polarity, and attachment chemistry are key variables. This makes the compound a useful, experimentally tractable reagent for constructing targeted protein degradation probes and optimizing linker-dependent degradation performance.
Structure of 5197-65-9
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1,14-Dichloro-3,6,9,12-tetraoxatetradecane, provides a chemically defined, polyether-based spacer bearing terminal chlorides suitable for modular assembly. Its ether-rich scaffold supports conformational flexibility that can help tune the relative positioning of ligands in targeted protein degradation constructs. The terminal leaving groups enable reliable functionalization into PROTAC architectures, and the subsequent points below describe its structure and practical reactivity considerations in detail.
Structure: The linker is a chlorinated, polyether chain featuring multiple ether oxygen atoms distributed along a flexible aliphatic backbone. Two terminal carbon–chlorine bonds serve as electrophilic handles, while the ether linkages provide polarity and hydrogen-bond acceptor character that can influence solubility and conformational behavior.
Reactivity: The terminal chlorides are appropriate for nucleophilic substitution reactions used to connect this linker to complementary PROTAC fragments. In typical linker–ligand coupling strategies, nucleophiles such as oxygen or nitrogen donors can displace chloride under basic conditions, often in polar aprotic solvents. Reaction progress is generally governed by leaving-group ability and nucleophile strength, with catalysts rarely required when chloride activation is sufficient.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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