SPDP-PEG8-COOH

 CAS No.: 1334177-96-6  Cat No.: BP-501056  Purity: ≥95% 4.5  

SPDP-PEG8-COOH is a PEG-based PROTAC linker which is applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. It contains SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward amine and thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and DCC to form stable amide bonds. The water solubility properties of PEG linkers is enhanced by longer PEG chains.

SPDP-PEG8-COOH

Structure of 1334177-96-6

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Category
PROTAC Linker
Molecular Formula
C27H46N2O11S2
Molecular Weight
638.79
Appearance
Light Yellow or White Solid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DMSO
Appearance
Light Yellow or White Solid
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Synonyms
SPDP-PEG8-acid; OPSS-PEG8-COOH; 3-oxo-1-(pyridin-2-yldisulfanyl)-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid; alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-carboxy octa(ethylene glycol)
Boiling Point
768.5±60.0 °C at 760 mmHg
Density
1.2±0.1 g/cm3
InChI Key
DKWMKNTUPXBDLZ-UHFFFAOYSA-N
InChI
InChI=1S/C27H46N2O11S2/c30-25(5-24-41-42-26-3-1-2-6-29-26)28-7-9-34-11-13-36-15-17-38-19-21-40-23-22-39-20-18-37-16-14-35-12-10-33-8-4-27(31)32/h1-3,6H,4-5,7-24H2,(H,28,30)(H,31,32)
Canonical SMILES
C1=CC=NC(=C1)SSCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

Stock concentration: *
Desired final volume: *
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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
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Historical Records: Mal-PEG5-PFP ester | m-PEG15-NHS ester | DBCO-PEG8-NHS ester | Mal-PEG2-NH-Boc | Benzyl-PEG7-NHBoc | m-PEG3-aldehyde | mPEG6-bromide | Bromo-PEG3-azide | Boc-Pip-alkyne-Ph-COOH | NH-bis(PEG4-C2-NH-Boc) | SPDP-PEG8-COOH

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