4,7,10,13-Tetraoxahexadeca-1,15-diyne
CAS No.: 126422-58-0
Cat No.: BP-500623
Purity: >95%
4.5 
4,7,10,13-Tetraoxahexadeca-1,15-diyne is a polyethylene glycol–like ether linker architecture featuring two terminal alkyne groups separated by an extended, oxygen-rich chain. The alternating ether units provide conformational flexibility and improved solvation, while the diyne termini enable orthogonal chemical handles for coupling strategies commonly used in PROTAC synthesis. In targeted protein degradation constructs, such linkers are employed to tune the spatial relationship between a ligand-binding warhead and an E3-recruiting moiety, thereby optimizing productive ternary complex formation and degradation efficiency. The long, oxygenated backbone can reduce steric strain and help maintain favorable linker geometry, which is critical because linker length and rigidity strongly influence ubiquitination kinetics and cellular potency. This compound is therefore valuable for researchers seeking modular, alkyne-functionalized linkers to build and systematically optimize PROTACs and related bifunctional degraders, including workflows that use alkyne-compatible conjugation chemistry for rapid analog generation.
Structure of 126422-58-0
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| -- | $-- | In stock |
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| ConcentrationVolumeMass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.4195 mL | 22.0975 mL | 44.1950 mL |
| 5 mM | 0.8839 mL | 4.4195 mL | 8.8390 mL |
| 10 mM | 0.4419 mL | 2.2097 mL | 4.4195 mL |
4,7,10,13-Tetraoxahexadeca-1,15-diyne, is designed to provide a rigid, well-defined spacer between targeting and E3-ligase-binding modules. Its oxygen-rich scaffold supports favorable conformational behavior and solubility tuning, while the terminal alkyne handles enable modular assembly. Such linkers are widely used in targeted protein degradation workflows to optimize linker length, geometry, and attachment chemistry, improving the reliability of conjugate synthesis.
Structure: The linker contains an internal polyether framework with multiple ether oxygen atoms and two terminal alkyne functionalities. It features carbon–carbon triple bonds at the termini and ether linkages along the backbone, yielding a polar, conformationally informative spacer with chemical stability suited to iterative PROTAC synthesis.
Reactivity: The terminal alkynes are compatible with common PROTAC conjugation strategies that rely on alkyne functional group reactivity, including copper-catalyzed azide–alkyne cycloaddition and related click-type coupling approaches. Typical conditions use copper catalysts, appropriate ligands, and polar organic solvents under inert or controlled atmospheres to minimize side reactions and preserve sensitive functional groups on the binding partners.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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