Name: Azido-PEG20-alcohol
Brand: BOC Sciences
Rating: 5 (1 reviews)

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$--

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Purity

90%

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

Synonyms

alpha-Azido-omega-hydroxy icosa(ethylene glycol);59-AZIDO-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-NONADECAOXANONAPENTACONTAN-1-OL

InChI Key

FRLHZVCZJNPUMK-UHFFFAOYSA-N

InChI

InChI=1S/C40H81N3O20/c41-43-42-1-3-45-5-7-47-9-11-49-13-15-51-17-19-53-21-23-55-25-27-57-29-31-59-33-35-61-37-39-63-40-38-62-36-34-60-32-30-58-28-26-56-24-22-54-20-18-52-16-14-50-12-10-48-8-6-46-4-2-44/h44H,1-40H2

SMILES

C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)N=[N+]=[N-]

Azido-PEG20-alcohol is a polyethylene glycol (PEG)-based linker bearing a terminal azide group, enabling modular attachment to targeting ligands in PROTAC construction. Its flexible, hydrophilic PEG scaffold supports favorable linker solvation and conformational mobility, while the azide handle provides a reliable chemical “click” site for conjugation. The subsequent points describe its structural features and practical reactivity considerations for assembling PROTACs in research workflows.

Structure: The linker consists of a PEG ether chain terminating in an azide functional group and a primary alcohol. It contains multiple ether linkages that confer flexibility and water compatibility, along with an azide moiety suitable for bioorthogonal conjugation. Overall, it is an amphiphilic, polar organic scaffold.

Reactivity: The terminal azide enables copper-catalyzed azide–alkyne cycloaddition with appropriately functionalized alkynes, or strain-promoted azide–alkyne cycloaddition when using cyclooctynes. Typical conjugation is performed under mild, aqueous or mixed-solvent conditions compatible with sensitive ligands, using Cu(I) sources and stabilizing ligands for the copper route. Solvent choice and pH should be optimized to maintain ligand integrity and maximize coupling efficiency.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂