Bromo-PEG2-t-butyl ester
CAS No.: 1381861-91-1
Cat No.: BP-501271
Purity: ≥95%
4.5 
Bromo-PEG2-t-butyl ester is a bifunctional PEG-based linker featuring a terminal bromo leaving group and a short, two–ethylene glycol unit chain capped as a tert-butyl ester. The short PEG segment provides aqueous compatibility and conformational flexibility, while the bromo handle enables chemoselective attachment to nucleophilic motifs (for example, via substitution with amines or other nucleophiles) to install the linker onto a warhead or other PROTAC-relevant fragment. The tert-butyl ester serves as a protected carboxylate that can be deprotected under appropriate conditions to reveal a reactive acid for subsequent coupling, allowing staged synthesis and modular assembly. In PROTAC design, such linkers help position the two binding elements to favor formation of the ternary complex by reducing steric constraints and improving solubility, which can enhance measurable degradation activity. This product is therefore useful for constructing degraders and related conjugates where controlled linker length, orthogonal functional handles, and reliable stepwise functionalization are required.
Structure of 1381861-91-1
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Bromo-PEG2-t-butyl ester is a PEG-based, bromo-functional linker designed to support modular PROTAC assembly by providing an electrophilic handle for controlled conjugation and a protected carboxylate for subsequent coupling steps. Its ether-rich PEG segment supports aqueous compatibility and can help tune linker flexibility in targeted protein degradation constructs. The points below describe its structure and practical reactivity considerations for PROTAC synthesis.
Structure: The linker contains an alkyl bromide electrophile and a short polyethylene glycol spacer, terminating in a tert-butyl ester. It features ether linkages within the PEG segment and an ester carbonyl, offering a balance of polarity, conformational flexibility, and protected carboxyl functionality.
Reactivity: The bromo group is suitable for nucleophilic substitution or related coupling strategies with appropriate nucleophiles under standard organic synthesis conditions. The tert-butyl ester can be used as a protected carboxylate during earlier steps, then deprotected using commonly employed acid-mediated ester cleavage to reveal the free acid for amide or related bond formation. Solvent systems and bases should be selected to maintain linker integrity and match the nucleophile reactivity used in PROTAC workflows.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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