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PT-179 - CAS 2924858-25-1

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PT-179 is an orthogonal thalidomide derivative used as a ligand for E3 ubiquitin ligase in PROTAC (proteolytic targeted chimera) technology. In PROTACs, PT-179 binds to CRBN, forms a ternary complex with the target protein fused to zinc finger (ZF) degron, and mediates the degradation of the tagged protein. This tagging process marks the target protein for degradation by the proteasome. By harnessing this mechanism, PT-179 is able to selectively remove proteins associated with various diseases, including cancer and neurodegenerative diseases. Therefore, PT-179 is a key component in the development of targeted protein degradation therapies.

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Molecular Formula
C17H17N3O5
Molecular Weight
343.33

PT-179

    • Specification
      • Purity
        ≥95%
        Solubility
        Soluble in DMSO
        Appearance
        Light yellow to yellow solid
        Storage
        Store at 2-8 °C
        IUPAC Name
        2-(2,6-dioxopiperidin-3-yl)-5-morpholin-4-ylisoindole-1,3-dione
        Synonyms
        2-(2,6-Dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-morpholinyl)-; PT 179; PT179
    • Properties
      • Boiling Point
        643.7±55.0 °C at 760 mmHg
        Density
        1.460±0.06 g/cm3
        InChI Key
        CCCSRHUSXCBFJZ-UHFFFAOYSA-N
        InChI
        InChI=1S/C17H17N3O5/c21-14-4-3-13(15(22)18-14)20-16(23)11-2-1-10(9-12(11)17(20)24)19-5-7-25-8-6-19/h1-2,9,13H,3-8H2,(H,18,21,22)
        Canonical SMILES
        C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)N4CCOCC4
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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