Tbdms-PEG4-alcohol

 CAS No.: 134179-40-1  Cat No.: BP-501120  Purity: ≥95% 4.5  

Tbdms-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It contains a TBDMS alcohol protecting group and a terminal hydroxyl group. TBDMS can be removed in the presence of acetyl chloride. The hydroxyl group can be derived into other compounds by other reactions. The hydrophilic PEG linker can increase the solubility of compounds in aqueous media.

Tbdms-PEG4-alcohol

Structure of 134179-40-1

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Category
PROTAC Linker
Molecular Formula
C14H32O5Si
Molecular Weight
308.49
Appearance
Colorless Oily Matter

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DMSO
Appearance
Colorless Oily Matter
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
2-[2-[2-[2-[tert-butyl(dimethyl)silyl]oxyethoxy]ethoxy]ethoxy]ethanol
Synonyms
TBDMS-PEG5; 13,13,14,14-Tetramethyl-3,6,9,12-tetraoxa-13-sila-1-pentadecanol; 2,2,3,3-Tetramethyl-4,7,10,13-tetraoxa-3-silapentadecan-15-ol; 2-[2-(2-TBDMSO-ethoxy)ethoxy]ethoxy]ethanol; TBDMS-PEG4-OH
Boiling Point
349.6±27.0 °C at 760 mmHg
Density
1.0±0.1 g/cm3
InChI Key
KZFZMISGZPOLJM-UHFFFAOYSA-N
InChI
InChI=1S/C14H32O5Si/c1-14(2,3)20(4,5)19-13-12-18-11-10-17-9-8-16-7-6-15/h15H,6-13H2,1-5H3
Canonical SMILES
CC(C)(C)[Si](C)(C)OCCOCCOCCOCCO

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: Bromo-PEG2-phosphonic acid | Thiol-PEG3-phosphonic acid | N-Boc-PEG36-alcohol | mPEG4-alcohol | NHS-Ac-N3 | Azido-PEG2-C2-sulfonic acid | Azido-PEG4-amido-tri-(carboxyethoxymethyl)-methane | Propargyl-PEG4-amine | BCN-POE3-amine | Ald-Ph-PEG24-NHS ester | Tbdms-PEG4-alcohol

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