Tbdms-PEG4-alcohol
CAS No.: 134179-40-1
Cat No.: BP-501120
Purity: ≥95%
4.5 
Tbdms-PEG4-alcohol is a protected, terminally functional polyethylene glycol linker designed for PROTAC synthesis. Structurally, it consists of a four-unit PEG chain providing hydrophilicity and conformational flexibility, capped with a tert-butyldimethylsilyl (TBDMS) group that protects the alcohol functionality during multi-step coupling and deprotection workflows. In PROTAC architectures, PEG linkers commonly serve as spacer elements that reduce steric interference between the target-binding ligand and the E3 ligase-recruiting moiety, while also improving aqueous solubility and enabling productive ternary complex formation. The protected alcohol handle allows controlled conjugation to electrophilic partners (e.g., via esterification, ether formation, or further derivatization), and subsequent deprotection can reveal the reactive terminus for final assembly. This reagent is valuable for researchers optimizing linker length, polarity, and synthetic compatibility to enhance targeted protein degradation performance.
Structure of 134179-40-1
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Tbdms-PEG4-alcohol is a PEG-based PROTAC linker building block incorporating a tert-butyldimethylsilyl-protected alcohol functionality. It is designed to provide controlled hydrophilicity and conformational flexibility, supporting effective spatial organization between a ligand and an E3-recruiting or target-binding module in targeted protein degradation constructs. Its protected handle enables staged synthetic assembly, and its subsequent deprotection can reveal a reactive alcohol for coupling. The structure and reactivity considerations are described in detail below.
Structure: The molecule is a PEG chain terminated with a silyl-protected alcohol, featuring ether linkages along the polymeric backbone and a silicon–oxygen protecting group. The presence of the tert-butyldimethylsilyl (TBDMS) group increases stability toward moisture and mild bases while maintaining a latent hydroxyl for later functionalization.
Reactivity: The silyl-protected alcohol can be carried through coupling steps under conditions compatible with TBDMS ethers. For PROTAC assembly, the alcohol is typically converted into an activated derivative (for example, via standard alcohol activation chemistry) or used after deprotection to enable ester or ether bond formation with complementary functional groups on ligands. TBDMS removal is commonly achieved using fluoride-based or mild acid conditions, followed by immediate coupling in suitable polar solvents to minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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