PT-179

Name: PT-179
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 2924858-25-1

Cat No.: BP-200105

Purity: ≥95% 4.5

PT-179 is an orthogonal thalidomide derivative used as a ligand for E3 ubiquitin ligase in PROTAC (proteolytic targeted chimera) technology. In PROTACs, PT-179 binds to CRBN, forms a ternary complex with the target protein fused to zinc finger (ZF) degron, and mediates the degradation of the tagged protein. This tagging process marks the target protein for degradation by the proteasome. By harnessing this mechanism, PT-179 is able to selectively remove proteins associated with various diseases, including cancer and neurodegenerative diseases. Therefore, PT-179 is a key component in the development of targeted protein degradation therapies.

Structure of 2924858-25-1

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Category

Ligand for E3 Ligase

Molecular Formula

C17H17N3O5

Molecular Weight

343.33

Appearance

Light yellow to yellow solid

* For research and manufacturing use only. Not for human or clinical use.

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Purity

≥95%

Solubility

Soluble in DMSO

Appearance

Light yellow to yellow solid

Storage

Store at 2-8 °C

IUPACName

2-(2,6-dioxopiperidin-3-yl)-5-morpholin-4-ylisoindole-1,3-dione

Synonyms

2-(2,6-Dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-morpholinyl)-; PT 179; PT179

Boiling Point

643.7±55.0 °C at 760 mmHg

Density

1.460±0.06 g/cm3

InChI Key

CCCSRHUSXCBFJZ-UHFFFAOYSA-N

InChI

InChI=1S/C17H17N3O5/c21-14-4-3-13(15(22)18-14)20-16(23)11-2-1-10(9-12(11)17(20)24)19-5-7-25-8-6-19/h1-2,9,13H,3-8H2,(H,18,21,22)

Canonical SMILES

C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)N4CCOCC4

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂