Azido-PEG6-C1-Boc
CAS No.: 297162-49-3
Cat No.: BP-500458
Purity: 98%
4.5 
Azido-PEG6-C1-Boc is a heterobifunctional PEG linker with an azide and a protected acid. Structurally, it contains a terminal azide connected through PEG6 to an acetic acid protected as a tert-butyl ester. The azide participates in CuAAC or SPAAC with complementary alkyne partners, while acid-mediated tert-butyl ester cleavage releases a carboxylic acid for amide or ester formation. In PROTAC and related targeted protein degradation research, the two different functional classes support click-mediated installation of one component and acid-based coupling of another without involving a Boc-protected amine. Its defined architecture allows researchers to evaluate how linker polarity, flexibility, attachment sequence, and terminal-group selection influence conjugate preparation and the spatial requirements of productive target–E3 ligase engagement. Clear assignment of the protected and reactive groups also supports reproducible reaction planning and systematic comparison of alternative linker designs in research-focused targeted protein degradation workflows.
Structure of 297162-49-3
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* For research and manufacturing use only. Not for human or clinical use.
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Azido-PEG6-C1-Boc is a PEG-based PROTAC linker bearing an azide handle and a protected functional group, enabling modular assembly of targeted protein degraders. Its flexible ethylene glycol segment supports productive spatial presentation of binding motifs, while the azide facilitates bioorthogonal conjugation strategies commonly used in PROTAC workflows. The Boc protection provides a controlled synthetic handle for stepwise coupling. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a polyethylene glycol chain that provides conformational flexibility, terminated by an azide-bearing substituent and a Boc-protected functional group. It contains ether linkages characteristic of PEG, with an azide moiety suitable for selective click-type reactions, and carbamate functionality associated with Boc protection.
Reactivity: The azide enables copper(I)-catalyzed azide–alkyne cycloaddition or related azide conjugation approaches under conditions that preserve sensitive ligands. The Boc group is typically removed under mild acid to reveal a reactive amine for subsequent amide or urea-forming couplings. Common coupling chemistries use activated carboxylic acids with base in polar aprotic solvents, while click steps are performed with appropriate catalysts and inert atmosphere when required.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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