Biotin-PEG3-hydrazide
CAS No.: 1381861-94-4
Cat No.: BP-501318
Purity: >95%
4.5 
Biotin-PEG3-hydrazide is a heterobifunctional linker combining a biotin handle with a short polyethylene glycol spacer and a terminal hydrazide for covalent coupling. The PEG3 segment provides aqueous solubility and spatial separation, reducing steric interference between the biotin moiety and the hydrazide-reactive group. In PROTAC and targeted protein degradation workflows, this linker is valuable as a modular attachment point: the biotin enables strong, high-affinity capture or enrichment using streptavidin/avidin reagents, while the hydrazide can be used to form hydrazone linkages with aldehyde-bearing partners under mild conditions, facilitating conjugation to targeting or reporting components. Researchers can exploit this design to assemble degraders or assay constructs with improved handling, purification, and controlled attachment chemistry, supporting studies that require efficient immobilization, pull-down validation of ternary-complex formation, or streamlined characterization of degradation ligands.
Structure of 1381861-94-4
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Biotin-PEG3-hydrazide is a polyethylene glycol (PEG)-based linker designed to support PROTAC assembly by combining a hydrazide functional group with a biotin handle for downstream conjugation and analytical workflows. Its flexible, ether-rich PEG segment promotes productive ternary-complex formation and improves solubility, while the hydrazide enables chemoselective coupling to carbonyl-bearing partners commonly used in targeted degradation strategies. The structure and reactivity considerations are described in detail below.
Structure: The linker contains a PEG chain featuring ether linkages that confer conformational flexibility and enhanced aqueous compatibility. A terminal hydrazide provides an electrophilic carbonyl for condensation chemistry, while the biotin moiety offers a high-affinity recognition element. Overall, it is an amide/ hydrazide-containing, polar, and water-soluble construct.
Reactivity: The hydrazide group is suitable for carbonyl-activation/condensation-based conjugation, including formation of hydrazone linkages with aldehyde or ketone partners under mild, dehydrating conditions. Typical PROTAC-building workflows employ controlled pH, inert atmosphere when required, and polar organic solvents compatible with PEG and amide stability. Reaction progress is often monitored by chromatographic or spectroscopic methods, and coupling is generally driven by equilibrium toward product formation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
