Pomalidomide-PEG2-CO2H

 CAS No.: 2140807-17-4  Cat No.: BP-100019  Purity: ≥98% 4.5  

Pomalidomide-PEG2-CO2H is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal carboxylic acid for reactivity with an amine on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.

Pomalidomide-PEG2-CO2H

Structure of 2140807-17-4

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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C20H23N3O8
Molecular Weight
433.41
Appearance
Yellow Solid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥98%
Solubility
Soluble in DMSO
Appearance
Yellow Solid
ShelfLife
2 years
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
IUPACName
3-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]propanoic acid
Synonyms
Thalidomide-NH-PEG2-COOH; Pomalidomide-PEG2-C2-acid; Pomalidomide-PEG2-COOH; Pomalidomide 4'-PEG2-acid; Pomalidomide-PEG2-C2-COOH; 3-[2-(2-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]propanoic acid; Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-; 3-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)propanoic acid; Pomalidomide-PEG2-CH2CH2COOH
Boiling Point
744.6±60.0°C at 760 mmHg
Density
1.5±0.1 g/cm3
InChI Key
NKISJPXMSOQWER-UHFFFAOYSA-N
InChI
InChI=1S/C20H23N3O8/c24-15-5-4-14(18(27)22-15)23-19(28)12-2-1-3-13(17(12)20(23)29)21-7-9-31-11-10-30-8-6-16(25)26/h1-3,14,21H,4-11H2,(H,25,26)(H,22,24,27)
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCC(=O)O

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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