Pomalidomide-PEG1-CO2H

 CAS No.: 2139348-60-8  Cat No.: BP-100018  Purity: ≥98% 4.5  

Pomalidomide-PEG1-CO2H is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal carboxylic acid for reactivity with an amine on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.

Pomalidomide-PEG1-CO2H

Structure of 2139348-60-8

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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C18H19N3O7
Molecular Weight
389.36
Appearance
Solid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥98%
Solubility
Soluble in DMSO
Appearance
Solid
ShelfLife
2 years
Storage
Store at 2-8°C, stored under nitrogen, away from moisture
IUPACName
3-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]propanoic acid
Synonyms
Thalidomide-NH-PEG1-COOH; Pomalidomide-PEG1-C2-COOH; Pomalidomide-PEG1-COOH; Pomalidomide-PEG1-CH2CH2COOH; 3-(2-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)propanoic acid; Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-; 3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid
Boiling Point
726.2±60.0°C at 760 mmHg
Density
1.5±0.1 g/cm3
InChI Key
GXCGXOBFROXMLV-UHFFFAOYSA-N
InChI
InChI=1S/C18H19N3O7/c22-13-5-4-12(16(25)20-13)21-17(26)10-2-1-3-11(15(10)18(21)27)19-7-9-28-8-6-14(23)24/h1-3,12,19H,4-9H2,(H,23,24)(H,20,22,25)
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCC(=O)O

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It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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