cIAP1 Ligand-Linker Conjugates 11 Hydrochloride

Background Introduction

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a specialized chemical tool designed for the targeted degradation of proteins via the PROTAC (Proteolysis Targeting Chimera) strategy. The compound features a ligand selective for the cellular Inhibitor of Apoptosis Protein 1 (cIAP1) E3 ligase, tethered through a chemically optimized linker. These conjugates serve as critical building blocks in next-generation therapies and research focused on modulating protein homeostasis.

Mechanism

The cIAP1 Ligand-Linker Conjugates 11 Hydrochloride operates through the hijacking of the ubiquitin-proteasome pathway. By integrating a cIAP1-binding ligand and a linker moiety, this conjugate can be joined to a target protein ligand, forming a bifunctional molecule known as a PROTAC. Once the completed PROTAC brings the target protein into proximity with cIAP1 E3 ligase, it facilitates the ubiquitination and subsequent proteasomal degradation of the protein of interest, enabling selective and catalytic removal of disease-relevant proteins.

Applications

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride are widely used in drug discovery and chemical biology research. Their main applications include the rational design and synthesis of tailored PROTAC molecules, investigation of targeted protein degradation mechanisms, and exploration of cIAP1 E3 ligase functions. These conjugates accelerate the development of novel therapeutics for cancer, neurodegenerative diseases, and immune disorders by enabling validation and optimization of protein degradation strategies.

• Selective binding to cIAP1 enables precise targeting of the inhibitor of apoptosis pathway in PROTAC applications.
• Hydrochloride salt form ensures improved solubility and stability for efficient synthesis of next-generation targeted protein degraders.