Pomalidomide-PEG5-NH2 hydrochloride

 CAS No.: 2357117-23-6  Cat No.: BP-100167  Purity: ≥95% 4.5  

Pomalidomide-PEG5-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.

Pomalidomide-PEG5-NH2 hydrochloride

Structure of 2357117-23-6

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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C25H36N4O9.HCl
Molecular Weight
573.04

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Storage
Store at -20°C
IUPACName
4-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
Synonyms
Thalidomide-NH-PEG5-NH2 hydrochloride; Thalidomide-NH-PEG5-C2-NH2 hydrochloride; Pomalidomide-PEG5-C2-NH2 hydrochloride; 4-((17-amino-3,6,9,12,15-pentaoxaheptadecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride; 4-[(17-Amino-3,6,9,12,15-pentaoxaheptadec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride; 1H-Isoindole-1,3(2H)-dione, 4-[(17-amino-3,6,9,12,15-pentaoxaheptadec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
InChI Key
OOFYLIGYAMKSRB-UHFFFAOYSA-N
InChI
InChI=1S/C25H36N4O9.ClH/c26-6-8-34-10-12-36-14-16-38-17-15-37-13-11-35-9-7-27-19-3-1-2-18-22(19)25(33)29(24(18)32)20-4-5-21(30)28-23(20)31;/h1-3,20,27H,4-17,26H2,(H,28,30,31);1H
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCOCCN.Cl

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
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